EFFECT OF STRUCTURAL CHANGES OF POLYMERIC NETWORK OF CALCIUM ALGINATE PREPARED BY IONOTROPIC GELATION ON DRUG RELEASE

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VARSHOUSAZ J.; GAZOURI T.

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Journal: JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS) Year:2003 | Volume:7 | Issue:Supplement 2 Page(s): 167-175

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Title

EFFECT OF STRUCTURAL CHANGES OF POLYMERIC NETWORK OF CALCIUM ALGINATE PREPARED BY IONOTROPIC GELATION ON DRUG RELEASE

Author(s)

VARSHOUSAZ J. | GAZOURI T. | Issue Writer Certificate

Keywords

SODIUM ALGINATEQ4

HYDROGEL CROSS-LINKINGQ4

DRUG DELIVERYQ4

Abstract

Introduction. SODIUM ALGINATE is a natural hydrogel polymer that is used to modulate drug release as adelivery system. The objective of this study was to investigate the effect of processing and structural variables of calcium alginate gel beads, on the swelling characteristics, loading efficiency, and drug release behaviour of this polymer.Methods. The studied variables consisted of polymer and cross-linking agent (CaCI2) concentrations, type of gelling cations, solubility and percentage of loaded drug, curring time of the polymer, pH and particle size of the alginate beads. The beads were then coated with Eudragit S-100 and drug release profiles were chracterized.Results and Discussion. Increasing the SODIUM ALGINATE and CaCI2 concentration, prolonged the release time of caffeine (the model drug). Release kinetic of low-water-soluble drugs (i.e., theobromine) followed a zero-order kinetic while release of highly-water-soluble drugs was better fitted with a first order kinetic. Among the different cations which caused gelation. Ca2+ showed a better swelling profile. The effect of drug water solubility on the loading efficiency of beads, showed the order of caffeine <theophylline < theobromine. Increasing the curring time of the gels changeg the release kinetic of caffeine from first-order to Higuchi model. Drug loading method in the beads had no effect on the loading efficiency, while it was effective on the release profile of caffeine. Increasing the caffeine concentration in the beads, prolonged the release time of the drug. DSC studies confirmed an ionic interaction between calcium alginate and caffeine in high concentrations which slowed the drug release.

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APA: Copy

VARSHOUSAZ, J., & GAZOURI, T.. (2003). EFFECT OF STRUCTURAL CHANGES OF POLYMERIC NETWORK OF CALCIUM ALGINATE PREPARED BY IONOTROPIC GELATION ON DRUG RELEASE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 7(Supplement 2), 167-175. SID. https://sid.ir/paper/26684/en

Vancouver: Copy

VARSHOUSAZ J., GAZOURI T.. EFFECT OF STRUCTURAL CHANGES OF POLYMERIC NETWORK OF CALCIUM ALGINATE PREPARED BY IONOTROPIC GELATION ON DRUG RELEASE. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2003;7(Supplement 2):167-175. Available from: https://sid.ir/paper/26684/en

IEEE: Copy

J. VARSHOUSAZ, and T. GAZOURI, “EFFECT OF STRUCTURAL CHANGES OF POLYMERIC NETWORK OF CALCIUM ALGINATE PREPARED BY IONOTROPIC GELATION ON DRUG RELEASE,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 7, no. Supplement 2, pp. 167–175, 2003, [Online]. Available: https://sid.ir/paper/26684/en

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