PREPARATION OF NITROGLYCERIN BEADS USING CALCIUM ALGINATE

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VALIZADEH H.; SIAHI SHADBAD M.R.; ABHAR SOBH F.; DANESH M.A.; NOKHOUDCHI A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: PHARMACEUTICAL SCIENCES Year:2006 | Volume:- | Issue:4 Page(s): 55-61

Download Full-Text

Persian Verion

View:

1,187

Download:

Cites:

Information Journal Paper

Title

PREPARATION OF NITROGLYCERIN BEADS USING CALCIUM ALGINATE

Author(s)

Keywords

BEADQ2

NITROGLYCERINQ2

CALCIUM ALGINATEQ2

IONIC CROSS-LINKQ2

Abstract

Objectives: The use of slow release formulations will reduce the number of doses per day that is administered by patients. This study reports formulation and dissolution performance of alginate and carboxy methylcellulose based sustained release BEADs of NITROGLYCERIN. Methods: The BEADs were obtained by an emulsion/ionic cross-linking technique. Effects of polymer and ion concentration on the dissolution performance of drug were also evaluated. In vitro drug release from the BEADs was determined by means of USP dissolution apparatus I, using distilled water as a medium and HPLC analytical technique. To compare the dissolution profiles, several release models were tested such as Higuchi, zero order, first order, Weibull and Korsmeyer-Peppas. A model-independent dissolution efficiency (DE) at t8 was used as well. The similarity between two in vitro dissolution profiles was assessed by similarity factor (f2) as a pair-wise independent-model procedure. Results: Most of f2 values indicated the similarity between the dissolution profiles of the test and the reference product. The results obtained from fitting dissolution profile s to mathematical release models show that the rate constants (K) are significantly smaller in the case of formulations containing Al3+ with respect to formulations containing Ca2+ as cross-linker. When Al3+ was used as cross-linker the dissolution rate constant was remarkably smaller (slow release) when the Al3+ concentration was increased. Conclusion: Generally, it can be concluded that the cross-linking technique is a potential technique to prepare alginate BEADs containing liquid drug with slow release capability.

Cites

No record.

References

No record.

Cite

APA: Copy

VALIZADEH, H., SIAHI SHADBAD, M.R., ABHAR SOBH, F., DANESH, M.A., & NOKHOUDCHI, A.. (2006). PREPARATION OF NITROGLYCERIN BEADS USING CALCIUM ALGINATE. PHARMACEUTICAL SCIENCES, -(4), 55-61. SID. https://sid.ir/paper/48743/en

Vancouver: Copy

VALIZADEH H., SIAHI SHADBAD M.R., ABHAR SOBH F., DANESH M.A., NOKHOUDCHI A.. PREPARATION OF NITROGLYCERIN BEADS USING CALCIUM ALGINATE. PHARMACEUTICAL SCIENCES[Internet]. 2006;-(4):55-61. Available from: https://sid.ir/paper/48743/en

IEEE: Copy

H. VALIZADEH, M.R. SIAHI SHADBAD, F. ABHAR SOBH, M.A. DANESH, and A. NOKHOUDCHI, “PREPARATION OF NITROGLYCERIN BEADS USING CALCIUM ALGINATE,” PHARMACEUTICAL SCIENCES, vol. -, no. 4, pp. 55–61, 2006, [Online]. Available: https://sid.ir/paper/48743/en

Related Journal Papers