SYNTHESIS OF N- ACETONITRIL AND N- ETHYLAMINE- 3- HYDROXYPYRIDINONES AS IRON (III) CHELATORS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

SAGHAEI L.A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download Full-Text

Persian Verion

View:

1,650

Download:

Cites:

Information Journal Paper

Title

SYNTHESIS OF N- ACETONITRIL AND N- ETHYLAMINE- 3- HYDROXYPYRIDINONES AS IRON (III) CHELATORS

Author(s)

SAGHAEI L.A. | Issue Writer Certificate

Keywords

HYDROXYPYRIDINONESQ4

IRON CHELATING AGENTSQ4

Abstract

Background. The need of iron-chelating agents as orally active alternatives to desferal for the treatment of iron overload in thalassaemic patients, has stimulated considerable research efforts in the synthesis of new metal chelators. One of the member of HYDROXYPYRIDINONES (2,3- dimethyl-3- ) HYDROXYPYRIDINONES has so far received the most attention. This compound is rapidly glucuronidated into a non-chelating metabolite, which partly explains why high doses of the compound has to be used in order to achieve negative balance. This metabolic behavior has led the medicinal chemists to design compounds such as N-hydroxyalkyl derivatives which do not undergo extensive metabolism. The objective of the present work was to further synthesis and design new derivatives of HYDROXYPYRIDINONES (N- acetonitril and N-ethylamine derivatives) Methods. The synthesis route involves the benzylation of hydroxyl group of maltol (ethyl maltol) using benzyl chloride conversion of the benazylated maltol (ethyl maltol) to the N-acetonitril bezylated pyridinone derivatives by introducing the aminoacetonitril in pyridine solvent and cleavage of benzyl group by hydrogenation method or using the bromodimethyl borane to form the N-acetonitril or N- ethylamine- 3- HYDROXYPYRIDINONES respectively.Results. In this work three final compounds such as 1- (2- aminoethyl)- 2- methyl- 3-hydroxypyridin- 4- one, 1- (2- aminoethyl)- 2- ethyl- 3- hydroxypyridin-4- one and 1- cyanomethyl -2- methyl- 3- hydroxypyridin- 4- one were synthesized.Discussion. Identification and structural elucidation of compounds were achieved by IH NMR and Mass spectra, elemental analysis and through physical constants. The biological effects of compounds will be studied in the near future.

Cites

No record.

References

No record.

Cite

APA: Copy

SAGHAEI, L.A.. (2000). SYNTHESIS OF N- ACETONITRIL AND N- ETHYLAMINE- 3- HYDROXYPYRIDINONES AS IRON (III) CHELATORS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), 5(Supplement 2), 24-29. SID. https://sid.ir/paper/26736/en

Vancouver: Copy

SAGHAEI L.A.. SYNTHESIS OF N- ACETONITRIL AND N- ETHYLAMINE- 3- HYDROXYPYRIDINONES AS IRON (III) CHELATORS. JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS)[Internet]. 2000;5(Supplement 2):24-29. Available from: https://sid.ir/paper/26736/en

IEEE: Copy

L.A. SAGHAEI, “SYNTHESIS OF N- ACETONITRIL AND N- ETHYLAMINE- 3- HYDROXYPYRIDINONES AS IRON (III) CHELATORS,” JOURNAL OF RESEARCH IN MEDICAL SCIENCES (JRMS), vol. 5, no. Supplement 2, pp. 24–29, 2000, [Online]. Available: https://sid.ir/paper/26736/en

Related Journal Papers