THE EFFECT OF GARLIC ON CYCLOSPORINE-A–INDUCED HYPERLIPIDEMIA IN MALE RATS

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TAGHIZADEH AFSHARI A.; SHIRPOUR A.R.; DODANGEH BALAKHANI E.

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Journal: UROLOGY JOURNAL Year:2005 | Volume:2 | Issue:3 Page(s): 153-156

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Title

THE EFFECT OF GARLIC ON CYCLOSPORINE-A–INDUCED HYPERLIPIDEMIA IN MALE RATS

Author(s)

TAGHIZADEH AFSHARI A. | SHIRPOUR A.R. | DODANGEH BALAKHANI E. | Issue Writer Certificate

Keywords

CYCLOSPORINE

LOW-DENSITY LIPOPROTEIN

RAT

GARLIC

Abstract

Introduction: Cyclosporin A (CsA) is a potent immunosuppressive drug. However, it has adverse effects that include elevation of plasma LOW-DENSITY LIPOPROTEIN (LDL). This study was designed to determine the effect of GARLIC on CsA-induced hyperlipidemia in male RATs. Materials and Methods: Baseline serum blood samples from forty 10-month-old, male Wistar RATs were obtained. They received intraperitoneal (IP) injection of CsA (25 mg/kg) for 28 days. Blood samples were again obtained after the 28-day treatment. Sixteen of 40 RATs showed increased serum LDL levels. These 16 were divided into 2 groups of 8 RATs each. In the first (experimental) group, 8 RATs received GARLIC (tablets, 400 mg/d), CsA (25 mg/kg IP), and regular diet for 28 days. In the second (control) group, 8 RATs received the same regimen without the GARLIC tablets. At the end of the experiment, blood samples were taken from animals in both groups, and LDL levels were assessed.Results: The mean baseline LDL level in animals in the control group was 17.75±4.1 mg/dL. This increased to 21.5 ± 1.6 mg/dL after 28 days of CsA administration. After 28 more days, the mean LDL level increased to 25.4 ± 4.9 mg/dL (P=.004). In animals in the experimental group, the baseline LDL level was 23.8±3.7 mg/dL, which increased to 31.3±1.6 mg/dL after the first 28 days (P<.001). After the second 28 days, it decreased to 26.0±4.8 mg/dL (P=.06), and among 4 animals, the LDL level decreased more than 49%. Conclusion: In a Wistar RAT model, animals given cyclosporin A subsequently treated with GARLIC demonstrated reduced LDL levels compared with controls. This treatment may be useful in patients receiving organ transplantations.

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APA: Copy

TAGHIZADEH AFSHARI, A., SHIRPOUR, A.R., & DODANGEH BALAKHANI, E.. (2005). THE EFFECT OF GARLIC ON CYCLOSPORINE-A–INDUCED HYPERLIPIDEMIA IN MALE RATS . UROLOGY JOURNAL, 2(3), 153-156. SID. https://sid.ir/paper/270682/en

Vancouver: Copy

TAGHIZADEH AFSHARI A., SHIRPOUR A.R., DODANGEH BALAKHANI E.. THE EFFECT OF GARLIC ON CYCLOSPORINE-A–INDUCED HYPERLIPIDEMIA IN MALE RATS . UROLOGY JOURNAL[Internet]. 2005;2(3):153-156. Available from: https://sid.ir/paper/270682/en

IEEE: Copy

A. TAGHIZADEH AFSHARI, A.R. SHIRPOUR, and E. DODANGEH BALAKHANI, “THE EFFECT OF GARLIC ON CYCLOSPORINE-A–INDUCED HYPERLIPIDEMIA IN MALE RATS ,” UROLOGY JOURNAL, vol. 2, no. 3, pp. 153–156, 2005, [Online]. Available: https://sid.ir/paper/270682/en

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