ETHYLENEDICYSTEINE VERSUS DIETHYLENETRIAMINE PENTAACETIC ACID AS THE CARRIER OF TECHNETIUM TC 99M IN DIURETIC RENOGRAPHY FOR PATIENTS WITH UPPER URINARY TRACT OBSTRUCTION

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SHAHROKH H.; MOVAHHED M.; ZARGAR SHOUSHTARI M.A.; ORAFA A.M.; HEKMAT S.

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Journal: UROLOGY JOURNAL Year:2006 | Volume:3 | Issue:2 Page(s): 97-103

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Title

ETHYLENEDICYSTEINE VERSUS DIETHYLENETRIAMINE PENTAACETIC ACID AS THE CARRIER OF TECHNETIUM TC 99M IN DIURETIC RENOGRAPHY FOR PATIENTS WITH UPPER URINARY TRACT OBSTRUCTION

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Keywords

RADIOISOTOPE RENOGRAPHY

KIDNEY FUNCTION

DIETHYLENETRIAMINE PENTAACETIC ACID

L- ETHYLENEDICYSTEINE

RADIOPHARMACEUTICAL

URETERAL OBSTRUCTION

Abstract

Introduction: L,L-ethylenedicysteine (EC) is a new carrier of technetium Tc 99m (99mTc) with a Lower affinity to plasma albumin in comparison with DIETHYLENETRIAMINE PENTAACETIC ACID (DTPA). We compared 99mTc-EC scan with 99mTc-DTPA scan in diuretic renography for patients with obstructive uropathy. Materials and Methods: Thirty-three patients with upper urinary tract obstruction were randomly selected and underwent diuretic renographies by 99mTc-EC and 99mTc- DTPA. The counts of radioisotope per pixel in the target (the kidney) and background tissues as well as the clearance half-life of these two RADIOPHARMACEUTICALs were measured and compared. Results: Mean counts of radioisotope per pixel in the target tissue was not different between 99mTc-EC and 99mTc-DTPA scans, but in the background tissue, it was Less for99mTc-EC (P = .003). Target-background ratio was higher for 99mTc-EC scan (3.80 ± 2.11 versus 2.48 ± 1.39; P < .001). Renal clearance half-life of radioisotope was shorter for 99mTc-EC scan than 99mTc-DTPA scan (58.15 ± 15.17 minutes versus 78.65 ± 19.99 minutes; P = .033). The results were similar for uremic patients (with a serum creatinine Level > 2mg/dL). Conclusion: Target-background ratio of RADIOPHARMACEUTICAL uptake rates in diuretic renography was a good indicator of the higher resolution of 99mTc-EC than 99mTc-DTPA scan. We also demonstrated the faster clearance of 99mTc-EC than 99mTc-DTPA. This results in Less radiation that is especially useful in children. To our opinion, 99mTc-EC can better depict the kidneys in comparison with 99mTc-DTPA.

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APA: Copy

SHAHROKH, H., MOVAHHED, M., ZARGAR SHOUSHTARI, M.A., ORAFA, A.M., & HEKMAT, S.. (2006). ETHYLENEDICYSTEINE VERSUS DIETHYLENETRIAMINE PENTAACETIC ACID AS THE CARRIER OF TECHNETIUM TC 99M IN DIURETIC RENOGRAPHY FOR PATIENTS WITH UPPER URINARY TRACT OBSTRUCTION. UROLOGY JOURNAL, 3(2), 97-103. SID. https://sid.ir/paper/270704/en

Vancouver: Copy

SHAHROKH H., MOVAHHED M., ZARGAR SHOUSHTARI M.A., ORAFA A.M., HEKMAT S.. ETHYLENEDICYSTEINE VERSUS DIETHYLENETRIAMINE PENTAACETIC ACID AS THE CARRIER OF TECHNETIUM TC 99M IN DIURETIC RENOGRAPHY FOR PATIENTS WITH UPPER URINARY TRACT OBSTRUCTION. UROLOGY JOURNAL[Internet]. 2006;3(2):97-103. Available from: https://sid.ir/paper/270704/en

IEEE: Copy

H. SHAHROKH, M. MOVAHHED, M.A. ZARGAR SHOUSHTARI, A.M. ORAFA, and S. HEKMAT, “ETHYLENEDICYSTEINE VERSUS DIETHYLENETRIAMINE PENTAACETIC ACID AS THE CARRIER OF TECHNETIUM TC 99M IN DIURETIC RENOGRAPHY FOR PATIENTS WITH UPPER URINARY TRACT OBSTRUCTION,” UROLOGY JOURNAL, vol. 3, no. 2, pp. 97–103, 2006, [Online]. Available: https://sid.ir/paper/270704/en

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