RELATIONSHIP BETWEEN EXPRESSION OF P53 PROTEIN AND TUMOR SUBTYPE AND GRADE IN RENAL CELL CARCINOMA

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

MOMBINI H.; GIVI M.; RASHIDI I.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: UROLOGY JOURNAL Year:2006 | Volume:3 | Issue:2 Page(s): 79-81

Download Full-Text

View:

330

Download:

122

Cites:

Information Journal Paper

Title

RELATIONSHIP BETWEEN EXPRESSION OF P53 PROTEIN AND TUMOR SUBTYPE AND GRADE IN RENAL CELL CARCINOMA

Author(s)

MOMBINI H. | GIVI M. | RASHIDI I. | Issue Writer Certificate

Keywords

RENAL CELL CARCINOMA

P53 PROTEIN

TUMOR GRADE

TUMOR SUBTYPE

Abstract

Introduction: Our aim was to evaluate the overexpression of P53 PROTEIN, product of mutated TP53 gene, in histologic sections of the kidneys with RENAL CELL CARCINOMA (RCC) and its association with TUMOR GRADE and subtype. Materials and Methods: A total of 66 histologic sections of the kidneys of patients with the diagnosis of RCC were re-evaluated and TUMOR GRADE, TUMOR SUBTYPE, and p53 expression were determined. Results: Of the total 66 histologic sections with the diagnosis of RCC, 34 (51.5%), 27 (41%), and 5 (7.5%) were conventional, papillary, and chromophobe subtypes, respectively. Fifty-one (77.3%), 14 (21.2%), and 1 (1.5%) of tumors were grade 2, 3, and 4, respectively. Thirty (45.4%) sections were positive for p53 immunohistochemical staining. In 7 cases (20.6%) of the conventional tumors, p53 staining was positive, while 18 papillary (66.6%) and 5 chromophobe tumors (100%) had a positive staining for p53 (P < .001). Seventeen out of 51 grade 2 tumors (33.4%) and 12 out of 14 grade 3 tumors (85.7%) were positive for p53. The single case of grade 4 tumor was positive for P53 PROTEIN, too (P = .001). Conclusion: Increased expression of P53 PROTEIN is rather prevalent in RCC. This factor is associated with TUMOR GRADE and subtype. According to our findings, it is generally accompanied by nonconventional subtypes and higher TUMOR GRADEs.

Cites

No record.

References

No record.

Cite

APA: Copy

MOMBINI, H., GIVI, M., & RASHIDI, I.. (2006). RELATIONSHIP BETWEEN EXPRESSION OF P53 PROTEIN AND TUMOR SUBTYPE AND GRADE IN RENAL CELL CARCINOMA. UROLOGY JOURNAL, 3(2), 79-81. SID. https://sid.ir/paper/270706/en

Vancouver: Copy

MOMBINI H., GIVI M., RASHIDI I.. RELATIONSHIP BETWEEN EXPRESSION OF P53 PROTEIN AND TUMOR SUBTYPE AND GRADE IN RENAL CELL CARCINOMA. UROLOGY JOURNAL[Internet]. 2006;3(2):79-81. Available from: https://sid.ir/paper/270706/en

IEEE: Copy

H. MOMBINI, M. GIVI, and I. RASHIDI, “RELATIONSHIP BETWEEN EXPRESSION OF P53 PROTEIN AND TUMOR SUBTYPE AND GRADE IN RENAL CELL CARCINOMA,” UROLOGY JOURNAL, vol. 3, no. 2, pp. 79–81, 2006, [Online]. Available: https://sid.ir/paper/270706/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops