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Information Journal Paper

Title

CYTOTOXIC EFFECT OF SAFFRON STIGMA AQUEOUS EXTRACT ON HUMAN TRANSITIONAL CELL CARCINOMA AND MOUSE FIBROBLAST

Pages

  161-167

Abstract

 Introduction: Saffron has been suggested to have inhibitory effects on tumoral cells. We evaluated the cytotoxic effect of aqueous extract of saffron on human TRANSITIONAL CELL CARCINOMA (TCC) and mouse non-neoplastic FIBROBLAST cell lines.Materials and Methods: Human TCC 5637 cell line and mouse FIBROBLAST cell line (L929) were cultivated and incubated with different concentrations of aqueous extract of saffron stigma (50 mg/mL to 4000 mg/mL). Cytotoxic effect of saffron was evaluated by morphologic observation and 3-(4,5- dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide colorimetric assay after 24, 48, 72, and 120 hours in each cell line.Results: After 24 hours, morphological observations showed growth inhibitory effects at saffron extract concentrations higher than 200 mg/mL for L929 cells and at concentrations of 50 mg/mL to 200 mg/mL for the TCC cells. These changes became more prominent after 48 hours. However, significant growth inhibitory effects of the extract were shown at concentrations of 400 mg/mL and 800 mg/mL. Higher concentrations of saffron correlated inversely with cell population of both cell lines. Significant reduction of the survived cells was seen at concentrations of 400 mg/mL and 2000 mg/Ml for TCC and L929 cell lines, respectively. After 120 hours, decrease in the percentage of survived cells at higher concentrations of saffron extract was seen in both cell lines. At a concentration of 800 mg/mL, the survived L929 cells plummeted to less than 60% after 120 hours, while no TCC cells survived at this time. No L929 cells survived at 2000 mg/mL.Conclusion: Saffron aqueous extract has inhibitory effects on the growth of both TCC 5637 and normal L929 cell lines. This effect is dose dependent.

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    • Cite

    APA: Copy

    FEYZZADEH, B., TAVAKOL AFSHARI, J., RAKHSHANDEH, H., RAHIMI, ALI REZA, BOROUK, A., & DOUSTI, H.. (2008). CYTOTOXIC EFFECT OF SAFFRON STIGMA AQUEOUS EXTRACT ON HUMAN TRANSITIONAL CELL CARCINOMA AND MOUSE FIBROBLAST. UROLOGY JOURNAL, 5(3), 161-167. SID. https://sid.ir/paper/270844/en

    Vancouver: Copy

    FEYZZADEH B., TAVAKOL AFSHARI J., RAKHSHANDEH H., RAHIMI ALI REZA, BOROUK A., DOUSTI H.. CYTOTOXIC EFFECT OF SAFFRON STIGMA AQUEOUS EXTRACT ON HUMAN TRANSITIONAL CELL CARCINOMA AND MOUSE FIBROBLAST. UROLOGY JOURNAL[Internet]. 2008;5(3):161-167. Available from: https://sid.ir/paper/270844/en

    IEEE: Copy

    B. FEYZZADEH, J. TAVAKOL AFSHARI, H. RAKHSHANDEH, ALI REZA RAHIMI, A. BOROUK, and H. DOUSTI, “CYTOTOXIC EFFECT OF SAFFRON STIGMA AQUEOUS EXTRACT ON HUMAN TRANSITIONAL CELL CARCINOMA AND MOUSE FIBROBLAST,” UROLOGY JOURNAL, vol. 5, no. 3, pp. 161–167, 2008, [Online]. Available: https://sid.ir/paper/270844/en

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