EXPRESSION OF SURVIVIN AND ITS SPLICED VARIANTS IN BLADDER TUMORS AS A POTENTIAL PROGNOSTIC MARKER

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NOURAEI NAZILA; MOULA SEYED JAVAD; OUZHAND A.; PARVIN MAHMOUD; ZIAEI S.A.M.; HATEFI N.

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Journal: UROLOGY JOURNAL Year:2009 | Volume:6 | Issue:2 Page(s): 101-108

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Title

EXPRESSION OF SURVIVIN AND ITS SPLICED VARIANTS IN BLADDER TUMORS AS A POTENTIAL PROGNOSTIC MARKER

Author(s)

Keywords

SURVIVIN PROTEIN

APOPTOSIS

BLADDER NEOPLASMS

REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION

Abstract

Introduction: Survivin, a novel inhibitor of APOPTOSIS, is re-expressed in a vast majority of hu man cancers and is widely considered as a diagnostic marker of cancers. SURVIVIN PROTEIN regulates both cell division and APOPTOSIS. There are at least 5 spliced variants of the gene with different sub cellular localization and anti-apoptotic property. We examined the expression pattern of surviving and its 2 spliced variants, survivin-DEx3 and survivin-2B, and their prognostic values in archival collections of formalin-fixed paraffin-embedded samples of bladder tumors.Materials and Methods: Total RNA from formalin-fixed paraffinembedded samples (51 samples from 30 patients with bladder cancer and 5-year follow-up) were extracted and analyzed by semiquantitative REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION technique. Tissue distribution and sub cellular localization of SURVIVIN PROTEIN in tumor tissues was also examined by immunohistochemistry.Results: The expression of survivin, surviving DEx3, and survivin-2B were detected in 66.6%, 47.8%, and 54.7% of the specimens, respectively. The expression of survivin and survivin-DEx3 were preferentially elevated in tumors with higher grades, whereas survivin-2B expression was lower in highgrade tumors (P=.04). A reverse correlation was observed between survivin- 2B expression and high-grade tumors. Immunohistochemistry results also confirmed the nuclear localization of SURVIVIN PROTEIN within tumoral cells.Conclusion: We were successful in detecting the expression of survivin and its variants in formalin-fixed paraffin-embedded bladder samples. Furthermore, our results showed that overexpression of survivin and survivin-DEx3 in bladder tumors correlates with poor prognosis of bladder cancer. We suggest that survivin and its variants are suitable prognostic markers of bladder tumors.

Cites

DECREASED EXPRESSION OF BIOINFORMATICALLY PREDICTED PIWIL2-TARGETTING MICRORNAS, MIR-1267 AND MIR-2276 IN BREAST CANCER

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APA: Copy

NOURAEI, NAZILA, MOULA, SEYED JAVAD, OUZHAND, A., PARVIN, MAHMOUD, ZIAEI, S.A.M., & HATEFI, N.. (2009). EXPRESSION OF SURVIVIN AND ITS SPLICED VARIANTS IN BLADDER TUMORS AS A POTENTIAL PROGNOSTIC MARKER. UROLOGY JOURNAL, 6(2), 101-108. SID. https://sid.ir/paper/270900/en

Vancouver: Copy

NOURAEI NAZILA, MOULA SEYED JAVAD, OUZHAND A., PARVIN MAHMOUD, ZIAEI S.A.M., HATEFI N.. EXPRESSION OF SURVIVIN AND ITS SPLICED VARIANTS IN BLADDER TUMORS AS A POTENTIAL PROGNOSTIC MARKER. UROLOGY JOURNAL[Internet]. 2009;6(2):101-108. Available from: https://sid.ir/paper/270900/en

IEEE: Copy

NAZILA NOURAEI, SEYED JAVAD MOULA, A. OUZHAND, MAHMOUD PARVIN, S.A.M. ZIAEI, and N. HATEFI, “EXPRESSION OF SURVIVIN AND ITS SPLICED VARIANTS IN BLADDER TUMORS AS A POTENTIAL PROGNOSTIC MARKER,” UROLOGY JOURNAL, vol. 6, no. 2, pp. 101–108, 2009, [Online]. Available: https://sid.ir/paper/270900/en

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