Is the Double Dose Alpha-Blocker Treatment Superior Than the Single Dose in the Management Of Patients Suffering From Acute Urinary Retention Caused By Benign Prostatic Hyperplasia?

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Kara onder; Yazici Merve

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Journal Paper

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Journal: UROLOGY JOURNAL Year:2014 | Volume:11 | Issue:3 Page(s): 1673-1677

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Title

Is the Double Dose Alpha-Blocker Treatment Superior Than the Single Dose in the Management Of Patients Suffering From Acute Urinary Retention Caused By Benign Prostatic Hyperplasia?

Author(s)

Kara onder | Yazici Merve | Issue Writer Certificate

Keywords

acute disease

administration

oral

prostatic hyperplasia

drug therapy

treatment outcome

urinary retention

adrenergic alpha-1 receptor antagonists

Abstract

Purpose: To compare the efficacy and safety of single (tamsulosin) and double dose (tamsulosin + alfuzosin) alpha-blocker therapy for treating catheterized patients with acute urinary retention (AUR) due to benign prostatic hyperplasia (BPH). Materials and Methods: Seventy patients with AUR due to BPH were catheterized and randomized into two groups: the single dose group (0. 4 mg tamsulosin, 35 patients) and the double dose group (0. 4 mg tamsulosin + 10 mg alfuzosin, 35 patients). The catheter was removed after 3 days, and the patients were put on trial without catheter (TWOC). Results: Seventy males (mean age, 71. 2 years) were randomly assigned to receive double or single dose alpha-blocker (35 patients per group). The intent-to-treat population consisted of 70 males. Twenty-seven individuals in the double dose group and 19 in the single dose group did not require re-catheterization on the day of the TWOC (77% and 54%, respectively; P =. 003). Success using free-flow variables was also higher in the males who received double dose alpha-blocker compared with single dose therapy (48% vs. 40%; P =. 017). Conclusion: TWOC was more successful in males treated with double dose alpha-blockers, and the subsequent need for re-catheterization was also reduced. The side-effect profiles were similar in the single and double dose alpha-blocker groups and were consistent with the known pharmacology. These results state that double dose alpha-blocker treatment can be recommended for treating males after catheterization for AUR, which may reduce the need for re-catheterization.

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APA: Copy

Kara, onder, & Yazici, Merve. (2014). Is the Double Dose Alpha-Blocker Treatment Superior Than the Single Dose in the Management Of Patients Suffering From Acute Urinary Retention Caused By Benign Prostatic Hyperplasia?. UROLOGY JOURNAL, 11(3), 1673-1677. SID. https://sid.ir/paper/271099/en

Vancouver: Copy

Kara onder, Yazici Merve. Is the Double Dose Alpha-Blocker Treatment Superior Than the Single Dose in the Management Of Patients Suffering From Acute Urinary Retention Caused By Benign Prostatic Hyperplasia?. UROLOGY JOURNAL[Internet]. 2014;11(3):1673-1677. Available from: https://sid.ir/paper/271099/en

IEEE: Copy

onder Kara, and Merve Yazici, “Is the Double Dose Alpha-Blocker Treatment Superior Than the Single Dose in the Management Of Patients Suffering From Acute Urinary Retention Caused By Benign Prostatic Hyperplasia?,” UROLOGY JOURNAL, vol. 11, no. 3, pp. 1673–1677, 2014, [Online]. Available: https://sid.ir/paper/271099/en

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