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Information Journal Paper

Title

Recruiting Testicular Torsion Introduces an Azoospermic Mouse Model for Spermatogonial Stem Cell Transplantation

Pages

  1648-1655

Abstract

 Purpose: To investigate the long-term effect of testicular torsion on sperm parameters and testis structure in order to introduce a novel mice azoospermic model for spermatogonial stem cell transplantation. Materials and Methods: Unilateral testicular torsion was created. The animals were divided into two groups each containing 15 mice. They underwent 2 and 4 hours of unilateral testicular ischemia, respectively. All animals in this experiment were aged matched. The experimental (n = 5) groups were studied 2, 4 and 10 weeks after testicular ischemia reperfusion. Moreover, the left testes and epididymis were removed for sperm analysis and for weight and histopathological evaluation. Finally isolated spermatogonial stem cells were transplanted in the testes that underwent 2 hours of ischemia reperfusion, two weeks post-surgery. Results: All the investigated parameters demonstrated a sharp decline at 2, 4 and 10 weeks after testicular torsion, whereas 2-hour ischemia was found to be less injurious in testicular tissue structure. Two months after xenotransplantation, the transplanted cells were localized in the basal of the seminiferous tubules of the recipient ischemic testes. Conclusion: Torsion can cause permanent azoospermia in mouse. Also Testicular torsion 2 weeks after the 2 hours ischemia reperfusion may prove useful for recipient preparation for SSCs transplantation in mouse.

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    • Cite

    APA: Copy

    Azizollahi, Saeid, AFLATOONIAN, REZA, ASGHARI JAFARABADI, MOHAMMAD, BEHNAM, BABAK, Azizollahi, Gholamabbas, & KORUJI, MORTEZA. (2014). Recruiting Testicular Torsion Introduces an Azoospermic Mouse Model for Spermatogonial Stem Cell Transplantation. UROLOGY JOURNAL, 11(3), 1648-1655. SID. https://sid.ir/paper/271101/en

    Vancouver: Copy

    Azizollahi Saeid, AFLATOONIAN REZA, ASGHARI JAFARABADI MOHAMMAD, BEHNAM BABAK, Azizollahi Gholamabbas, KORUJI MORTEZA. Recruiting Testicular Torsion Introduces an Azoospermic Mouse Model for Spermatogonial Stem Cell Transplantation. UROLOGY JOURNAL[Internet]. 2014;11(3):1648-1655. Available from: https://sid.ir/paper/271101/en

    IEEE: Copy

    Saeid Azizollahi, REZA AFLATOONIAN, MOHAMMAD ASGHARI JAFARABADI, BABAK BEHNAM, Gholamabbas Azizollahi, and MORTEZA KORUJI, “Recruiting Testicular Torsion Introduces an Azoospermic Mouse Model for Spermatogonial Stem Cell Transplantation,” UROLOGY JOURNAL, vol. 11, no. 3, pp. 1648–1655, 2014, [Online]. Available: https://sid.ir/paper/271101/en

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