Effect of Age on Conversion to Everolimus with Calcineurin Inhibitor Minimization at A Late Post-Transplant Stage

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Uchida Junji; Nishide Shunji; Kabei Kazuya; Shimada Hisao; Kosoku Akihiro; Iwai Tomoaki; Kuwabara Nobuyuki; Naganuma Toshihide; Kumada Norihiko; Takemoto Yoshiaki; Nakatani Tatsuya

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Journal: UROLOGY JOURNAL Year:2018 | Volume:15 | Issue:5 Page(s): 266-271

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Title

Effect of Age on Conversion to Everolimus with Calcineurin Inhibitor Minimization at A Late Post-Transplant Stage

Author(s)

Keywords

age

calcineurin inhibitor minimization

everolimus

immunosuppressive agent

kidney transplantation

Abstract

Purpose: The purpose of this study was to identify the risk factors for everolimus discontinuation in kidney transplant recipients converted to everolimus with calcineurin inhibitor (CNI) minimization at a late post-transplant stage. Materials and Methods: An observational retrospective cohort study was conducted on a total of 38 recipients of kidney transplantation at our institution from June 2012 to March 2015 who were converted from antimetabolites to everolimus at a late post-transplant stage and followed for 1 year. We divided the patients into two groups to evaluate the factors affecting everolimus discontinuation after conversion: everolimus continuation group (n = 23), patients in whom everolimus maintained, and everolimus discontinuation group (n = 15), patients in whom everolimus were stopped within 1 year after conversion. Results: Age at conversion was significantly older in the everolimus discontinuation group compared to the everolimus continuation group (57. 9 ± 12. 0 years in the everolimus discontinuation group vs 45. 7 ± 11. 2 years in the everolimus continuous group; P =. 0062). Multivariate cox proportional hazard regression analysis revealed that age at conversion significantly correlated with everolimus discontinuation (P =. 012). Receiver operating characteristic curve of age at conversion showed that the cut-off value was 55 years old for the everolimus discontinuation group [area under curve 0. 804, 95% confidence interval (0. 654-0. 954), sensitivity 86. 7%, specificity 65. 2%]. Conclusion: Our results indicated that late conversion to everolimus with CNI minimization in elderly recipients older than 55 years of age may be associated with more frequent adverse events and discontinuations.

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APA: Copy

Uchida, Junji, Nishide, Shunji, Kabei, Kazuya, Shimada, Hisao, Kosoku, Akihiro, Iwai, Tomoaki, Kuwabara, Nobuyuki, Naganuma, Toshihide, Kumada, Norihiko, Takemoto, Yoshiaki, & Nakatani, Tatsuya. (2018). Effect of Age on Conversion to Everolimus with Calcineurin Inhibitor Minimization at A Late Post-Transplant Stage. UROLOGY JOURNAL, 15(5), 266-271. SID. https://sid.ir/paper/271241/en

Vancouver: Copy

Uchida Junji, Nishide Shunji, Kabei Kazuya, Shimada Hisao, Kosoku Akihiro, Iwai Tomoaki, Kuwabara Nobuyuki, Naganuma Toshihide, Kumada Norihiko, Takemoto Yoshiaki, Nakatani Tatsuya. Effect of Age on Conversion to Everolimus with Calcineurin Inhibitor Minimization at A Late Post-Transplant Stage. UROLOGY JOURNAL[Internet]. 2018;15(5):266-271. Available from: https://sid.ir/paper/271241/en

IEEE: Copy

Junji Uchida, Shunji Nishide, Kazuya Kabei, Hisao Shimada, Akihiro Kosoku, Tomoaki Iwai, Nobuyuki Kuwabara, Toshihide Naganuma, Norihiko Kumada, Yoshiaki Takemoto, and Tatsuya Nakatani, “Effect of Age on Conversion to Everolimus with Calcineurin Inhibitor Minimization at A Late Post-Transplant Stage,” UROLOGY JOURNAL, vol. 15, no. 5, pp. 266–271, 2018, [Online]. Available: https://sid.ir/paper/271241/en

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