Efficacy of Silodosin in Expulsive Therapy for Distal Ureteral Stones: A Randomized Double-blinded Controlled Trial

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Wang Chung Jing; Tsai Po Chao; Chang Chien Hsing

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Journal: UROLOGY JOURNAL Year:2016 | Volume:13 | Issue:3 Page(s): 2666-2671

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Title

Efficacy of Silodosin in Expulsive Therapy for Distal Ureteral Stones: A Randomized Double-blinded Controlled Trial

Author(s)

Wang Chung Jing | Tsai Po Chao | Chang Chien Hsing | Issue Writer Certificate

Keywords

adrenergic alpha-1 receptor antagonists

dose-response relationship

drug

follow-up studies

prospective studies

treatment outcome

ureteral calculi/drug therapy

Abstract

Purpose: To evaluate the efficacy of silodosin in the medical expulsive therapy for symptomatic distal ureteral stones. Materials and Methods: This prospectively randomized controlled trial was carried out from May 2011 to December 2014. In all, 198 patients with radiopaque distal ureteral stones <10 mm in size were eligible: 61 patients in the control group and 62 patients in the silodosin group. The silodosin group received silodosin 8 mg daily, and the control group received lactose tablets. The primary outcome was the expulsion rate. The secondary outcomes the expulsion time, analgesic consumption, lower urinary tract symptoms, colic episodes, and adverse effects. Statistical analyses were performed using a Mann-Whitney U-test and chi-square test. Results: The final analysis was conducted with 61 control and 62 silodosin patients as the denominator in each randomization arm. The average expulsion times were 6. 31 ± 2. 13 days for the silodosin group and 9. 73 ± 2. 76 days for the control group (P <. 001). Conclusion: Treatment with silodosin proved to be safe and effective, as demonstrated by the increased stone expulsion rate, the reduced expulsion time, and the reduced analgesics consumption.

Cites

REVIEW: Efficacy and Safety of Tamsulosin in the Medical Expulsion Therapy for Distal Ureteral Calculi: A Systematic Review and Meta-Analysis of Placebo-Controlled Trials

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APA: Copy

Wang, Chung Jing, Tsai, Po Chao, & Chang, Chien Hsing. (2016). Efficacy of Silodosin in Expulsive Therapy for Distal Ureteral Stones: A Randomized Double-blinded Controlled Trial. UROLOGY JOURNAL, 13(3), 2666-2671. SID. https://sid.ir/paper/271311/en

Vancouver: Copy

Wang Chung Jing, Tsai Po Chao, Chang Chien Hsing. Efficacy of Silodosin in Expulsive Therapy for Distal Ureteral Stones: A Randomized Double-blinded Controlled Trial. UROLOGY JOURNAL[Internet]. 2016;13(3):2666-2671. Available from: https://sid.ir/paper/271311/en

IEEE: Copy

Chung Jing Wang, Po Chao Tsai, and Chien Hsing Chang, “Efficacy of Silodosin in Expulsive Therapy for Distal Ureteral Stones: A Randomized Double-blinded Controlled Trial,” UROLOGY JOURNAL, vol. 13, no. 3, pp. 2666–2671, 2016, [Online]. Available: https://sid.ir/paper/271311/en

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