Association Study of Klotho Gene Polymorphism With Calcium Oxalate Stones in The Uyghur Population of Xinjiang, China

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Ali Abdusamat; Tursun Halmurat; Talat Alim; Abla Akpar; Muhtar Erpan; ZHANG TAO; Mahmut Murat

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Journal: UROLOGY JOURNAL Year:2017 | Volume:14 | Issue:1 Page(s): 2939-2944

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Title

Association Study of Klotho Gene Polymorphism With Calcium Oxalate Stones in The Uyghur Population of Xinjiang, China

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Keywords

case-control studies

genotype

Klotho gene

polymorphism

urolithiasis

Abstract

Purpose: The aim of the present study was to investigate the correlation between Klotho gene polymorphisms and calcium oxalate stones in Xinjiang Uyghur people. Materials and Methods: We compared 128 patients with calcium oxalate stones (case group) and 94 healthy people (control group), detected the genotype and allele distributions of single-nucleotide polymorphisms (SNPs) of the Klotho gene (rs3752472, rs650439, and rs1207568) by reverse transcription polymerase chain reaction. Results: The distributions of the genotype and allele frequencies of the SNPs were consistent with the Hardy– Weinberg equilibrium in the two groups. There were statistically significant differences between the genotype and allele distributions of rs3752472 between the case and control groups; the allele frequencies in the case/control groups were C = 240 (93. 7%)/151 (80. 3%) and T = 16 (6. 3%)/37 (19. 7%). There was no statistically significant difference in the genotype distribution of rs650439 between the case and control groups, but there was a difference in the allele distribution; the allele frequencies in the case/control groups were A = 202 (78. 9%)/143 (57. 2%) and T = 54 (21. 1%)/107 (42. 8%). There were no statistically significant differences in genotype and allele distributions between the case and control groups of rs1207568; the allele frequencies in the case/control groups were C = 194 (71. 3%)/145 (77. 1%) and T = 78 (28. 7%)/43 (22. 9%). In rs3752472, the risk for patients with the C and A alleles increased by 3. 675 and 2. 799 times, respectively. Conclusion: The rs3752472 and rs650439 SNPs are related to the risk of calcium oxalate stones in Xinjiang Uyghur people, and might be one of the risk factors.

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APA: Copy

Ali, Abdusamat, Tursun, Halmurat, Talat, Alim, Abla, Akpar, Muhtar, Erpan, ZHANG, TAO, & Mahmut, Murat. (2017). Association Study of Klotho Gene Polymorphism With Calcium Oxalate Stones in The Uyghur Population of Xinjiang, China. UROLOGY JOURNAL, 14(1), 2939-2944. SID. https://sid.ir/paper/271395/en

Vancouver: Copy

Ali Abdusamat, Tursun Halmurat, Talat Alim, Abla Akpar, Muhtar Erpan, ZHANG TAO, Mahmut Murat. Association Study of Klotho Gene Polymorphism With Calcium Oxalate Stones in The Uyghur Population of Xinjiang, China. UROLOGY JOURNAL[Internet]. 2017;14(1):2939-2944. Available from: https://sid.ir/paper/271395/en

IEEE: Copy

Abdusamat Ali, Halmurat Tursun, Alim Talat, Akpar Abla, Erpan Muhtar, TAO ZHANG, and Murat Mahmut, “Association Study of Klotho Gene Polymorphism With Calcium Oxalate Stones in The Uyghur Population of Xinjiang, China,” UROLOGY JOURNAL, vol. 14, no. 1, pp. 2939–2944, 2017, [Online]. Available: https://sid.ir/paper/271395/en

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