THE EFFECT OF HYDROALCOHOLIC EXTRACT OFNECTAROSCORDUM TRIPEDALE ON LIVER AND KIDNEY FUNCTIONAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS

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PAYDAR S.; JELODAR GH.; MOHAMMADI J.; MOHAMMADI N.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2016 | Volume:18 | Issue:2 Page(s): 112-119

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Title

THE EFFECT OF HYDROALCOHOLIC EXTRACT OFNECTAROSCORDUM TRIPEDALE ON LIVER AND KIDNEY FUNCTIONAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS

Author(s)

PAYDAR S. | JELODAR GH. | MOHAMMADI J. | MOHAMMADI N. | Issue Writer Certificate

Keywords

DIABETES MELLITUSQ3

NECTAROSCORDUM TRIPEDALEQ1

LIVERQ2

KIDNEYQ2

RATQ2

Abstract

Introduction: The reducing effects of some of tripedale family plants on blood glucose, lipids and enzymes have been reported. The aim of the present study was to assess the effects of the hydroalcoholic extract of NECTAROSCORDUM TRIPEDALE on LIVER and KIDNEY function in streptozotocininduced diabetic RATs.Materials and Methods: Forty male RATs were randomly divided into five groups (n=8 each). Groups 1, 3 (normal control and diabetic control) received distilled water, group 2 received 50 mg/kg/day NECTAROSCORDUM TRIPEDALE extract, and the groups 4 and 5 (treatment groups 1 and 2) received 50 and 100 mg/kg/day of the NECTAROSCORDUM TRIPEDALE extract respectively for 21 consecutive days. Diabetes was induced by a single injection of streptozotocin in RATs. At the end of the 21st day, blood samples were collected by heart puncture. Serum levels of ALP, AST, ALT, Alb, BUN, creatinine and urea were evaluated.Results: Results showed that the hydroalcoholic extract of NECTAROSCORDUM TRIPEDALE can increase the average body weight in the treatments groups. ALP, AST, ALT, BUN levels decreased, wherease level of albumin (Alb) increased in a dose-dependent manner at the end experimental period (P<0.05).Conclusion: Our results showed that the extract of NECTAROSCORDUM TRIPEDALE improved LIVER and KIDNEY function in a dose dependent manner in experimental conditions.

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APA: Copy

PAYDAR, S., JELODAR, GH., MOHAMMADI, J., & MOHAMMADI, N.. (2016). THE EFFECT OF HYDROALCOHOLIC EXTRACT OFNECTAROSCORDUM TRIPEDALE ON LIVER AND KIDNEY FUNCTIONAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 18(2), 112-119. SID. https://sid.ir/paper/27223/en

Vancouver: Copy

PAYDAR S., JELODAR GH., MOHAMMADI J., MOHAMMADI N.. THE EFFECT OF HYDROALCOHOLIC EXTRACT OFNECTAROSCORDUM TRIPEDALE ON LIVER AND KIDNEY FUNCTIONAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2016;18(2):112-119. Available from: https://sid.ir/paper/27223/en

IEEE: Copy

S. PAYDAR, GH. JELODAR, J. MOHAMMADI, and N. MOHAMMADI, “THE EFFECT OF HYDROALCOHOLIC EXTRACT OFNECTAROSCORDUM TRIPEDALE ON LIVER AND KIDNEY FUNCTIONAL PARAMETERS IN STREPTOZOTOCIN-INDUCED DIABETIC MALE RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 18, no. 2, pp. 112–119, 2016, [Online]. Available: https://sid.ir/paper/27223/en

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