مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

399
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

396
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

IMMUNOSUPPRESSIVE ACTIVITY OF LEISHMANIA MAJOR CULTURE SUPERNATANT

Pages

  22-27

Abstract

 BALB/c mice are highly susceptible to infection with the protozoan parasite LEISHMANIA MAJOR. This susceptibility has been attributed in part to the expansion of Th2 cells and production of their cytokines, IL-4 and IL-10 and down-regulation of Th1 cytokine, INF-γ. The inability of susceptible hosts to mount the immune response necessary to activate macrophage and destroy the parasites can be due to the parasite-specific proteins that are able to modulate the immune system. In this report, we monitored the culture supernatant of the parasite in order to show the existence of IMMUNOSUPPRESSIVE factor. The L. major parasites were isolated from lesion of infected BALB/c mice. AMASTIGOTEs were grown at 35 °C and PROMASTIGOTEs at 22-25°C in the presence of 10% FCS. Culture supernatants were harvested after 72 h of incubation and used for lymphocyte proliferation assay using lymph node and spleen cells stimulated with mitogens. We have shown that the excretory materials of PROMASTIGOTEs and axenic AMASTIGOTEs have a potent IMMUNOSUPPRESSIVE activity. Culture supernatants can suppress the proliferation of mitogen-stimulated lymph node lymphocytes (74%) or spleen cells (90%) in a dose-dependent manner. This result may show that parasite by excretory materials can influence INF-γ production by T cells and macrophage activation in order to survive within the macrophage and propagating inside the phagolysosome.      

Cites

  • No record.

    • References

    Cite

    APA: Copy

    ABOU ALHASANI, MOHSEN, & DARABI, HAYEDEH. (2006). IMMUNOSUPPRESSIVE ACTIVITY OF LEISHMANIA MAJOR CULTURE SUPERNATANT. IRANIAN JOURNAL OF PUBLIC HEALTH, 35(3), 22-27. SID. https://sid.ir/paper/272348/en

    Vancouver: Copy

    ABOU ALHASANI MOHSEN, DARABI HAYEDEH. IMMUNOSUPPRESSIVE ACTIVITY OF LEISHMANIA MAJOR CULTURE SUPERNATANT. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2006;35(3):22-27. Available from: https://sid.ir/paper/272348/en

    IEEE: Copy

    MOHSEN ABOU ALHASANI, and HAYEDEH DARABI, “IMMUNOSUPPRESSIVE ACTIVITY OF LEISHMANIA MAJOR CULTURE SUPERNATANT,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 35, no. 3, pp. 22–27, 2006, [Online]. Available: https://sid.ir/paper/272348/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button