Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

472
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

405
Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

ASSOCIATION OF ANGIOTENSIN CONVERTING ENZYME (ACE) GENE POLYMORPHISM AND DIABETIC NEPHROPATHY

Pages

  14-21

Abstract

 Angiotensin I-converting Enzyme (ACE) gene polymorphism; genotype DD or D allele may be involved with an increased susceptibility to type 2 diabetes and DIABETIC NEPHROPATHY (DN). We examined the frequency of ACE gene polymorphism in 170 patients (85 type 2 diabetes with nephropathy and 85 without it) in Tehran, IRAN. DNA was extracted from the white blood cells and the I/D polymorphism of the ACE gene was detected by PCR. The frequency of DD, ID and II genotypes in type 2 diabetic patients were 20%, 61.2% and 18.8%, and in patients with nephropathy 30.6%, 55.3%, 14.1%, respectively. The DD genotype of the DN group was higher than that of the type 2 diabetes patients (30.6% vs 20%, P=0.157, RR=1.3) and the control group (30.6% vs 14.3%, P=0.006, RR=2.9). The frequency of D allele in nephropathic patients was 58.2% as compared to the type 2 diabetic patients without nephropathy (50.5%) P=0.19, RR=1.16. The D allele frequency in the DN group was found slightly higher than of the type 2 diabetes (X2=0.684, OR=0.709, 95%CI: 0.313-1.606, P=0.408) which indicated the D allele was not associated with DN. It is suggested that DD genotype and D allele are not associated with DIABETIC NEPHROPATHY.      

Cites

  • No record.

    • References

    Cite

    APA: Copy

    GOLMOHAMMADI, T., NIKZAMIR, A., ZAHRAEI, M., NAKHJAVANI, M., SAFARI, R., & AMIRZARGAR, ALI AKBAR. (2006). ASSOCIATION OF ANGIOTENSIN CONVERTING ENZYME (ACE) GENE POLYMORPHISM AND DIABETIC NEPHROPATHY. IRANIAN JOURNAL OF PUBLIC HEALTH, 35(3), 14-21. SID. https://sid.ir/paper/272355/en

    Vancouver: Copy

    GOLMOHAMMADI T., NIKZAMIR A., ZAHRAEI M., NAKHJAVANI M., SAFARI R., AMIRZARGAR ALI AKBAR. ASSOCIATION OF ANGIOTENSIN CONVERTING ENZYME (ACE) GENE POLYMORPHISM AND DIABETIC NEPHROPATHY. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2006;35(3):14-21. Available from: https://sid.ir/paper/272355/en

    IEEE: Copy

    T. GOLMOHAMMADI, A. NIKZAMIR, M. ZAHRAEI, M. NAKHJAVANI, R. SAFARI, and ALI AKBAR AMIRZARGAR, “ASSOCIATION OF ANGIOTENSIN CONVERTING ENZYME (ACE) GENE POLYMORPHISM AND DIABETIC NEPHROPATHY,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 35, no. 3, pp. 14–21, 2006, [Online]. Available: https://sid.ir/paper/272355/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top