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Information Journal Paper

Title

ASSOCIATION BETWEEN ALZHEIMER ’S DISEASE AND APOLIPOPROTEIN E POLYMORPHISMS

Pages

  1-6

Abstract

 Background: Alzheimer’s disease as a neurodegenerative disorder is the commonest type of dementia. A growing number of genes have been reported as the risk factors, which increase the susceptibility to Alzheimer’s disease. APOLIPOPROTEIN E (APOE), which its !4 allele has been reported as a risk factor in late onset Alzheimer’s disease (AD), is the main cholesterol carrier in the brain. The main goal of this study was to assess the role of APOE genotypes and alleles in AD in IRANian population. Methods: This study was performed in Tehran, IRAN from 2007 to 2008. Totally, 154 AD cases and 162 control subjects from IRANian population were genotyped for APOE using PCR method. Genotype and alleles frequencies for APOE were calculated and compared between AD case and control subjects by 42 or Fisher’s exact test. Type one error assumed less than 0.05. Results: The frequency of e2e3 genotype was significantly higher in control subjects than AD patients was (13.5% versus 5.2%, P< 0.05) and e3e4 genotype frequency was significantly higher in AD cases compared with control subjects. APOE -e2 allele frequency in cases was lower than that of control subjects but this difference was not significant (4.2% versus 7.7%). Conclusion: It seems that individuals carrying e4 allele, develop AD 6.5 times more than non-carriers do (OR= 6.566, 95% CI= 2.89-14.92). It has been reported that e4 allele acts in dose- age-dependent manner but we have shown that the risk of developing AD in male APOE -!4 allele carriers is higher than that of female !4 carriers.

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    APA: Copy

    GOZALPOUR, E., KAMALI, K., MOHAMMAD, K., KHORAM KHOURSHID, H.R., OUHADI, M., KARIMLOU, M., MIRABZADEH, A., & FOTOUHI, A.. (2010). ASSOCIATION BETWEEN ALZHEIMER ’S DISEASE AND APOLIPOPROTEIN E POLYMORPHISMS. IRANIAN JOURNAL OF PUBLIC HEALTH, 39(2), 1-6. SID. https://sid.ir/paper/272716/en

    Vancouver: Copy

    GOZALPOUR E., KAMALI K., MOHAMMAD K., KHORAM KHOURSHID H.R., OUHADI M., KARIMLOU M., MIRABZADEH A., FOTOUHI A.. ASSOCIATION BETWEEN ALZHEIMER ’S DISEASE AND APOLIPOPROTEIN E POLYMORPHISMS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2010;39(2):1-6. Available from: https://sid.ir/paper/272716/en

    IEEE: Copy

    E. GOZALPOUR, K. KAMALI, K. MOHAMMAD, H.R. KHORAM KHOURSHID, M. OUHADI, M. KARIMLOU, A. MIRABZADEH, and A. FOTOUHI, “ASSOCIATION BETWEEN ALZHEIMER ’S DISEASE AND APOLIPOPROTEIN E POLYMORPHISMS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 39, no. 2, pp. 1–6, 2010, [Online]. Available: https://sid.ir/paper/272716/en

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