THE -514C/T POLYMORPHISM OF HEPATIC LIPASE GENE AMONG IRANIAN PATIENTS WITH CORONARY HEART DISEASE

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GHATREH SAMANI K.; NOORI M.; ROHBANI NOBAR M.; HASHEMZADEH CHALESHTORY M.; FARROKHI E.; DARABI AMIN M.

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Journal Paper

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Journal: Iranian Journal of Public Health Year:2012 | Volume:41 | Issue:1 Page(s): 59-65

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Title

THE -514C/T POLYMORPHISM OF HEPATIC LIPASE GENE AMONG IRANIAN PATIENTS WITH CORONARY HEART DISEASE

Author(s)

Keywords

HEPATIC LIPASE GENE

HDL-C

CORONARY ARTERY STENOSIS

T ALLELE

IRAN

Abstract

Background: The T ALLELE of the hepatic lipase (HL) C-514T polymorphism was previously found to be associated with lower plasma HL activity. Here, we examined the association between this polymorphism and plasma HDL-Cholesterol concentrations in patients with coronary arteries stenosis.Methods: We studied 342 subjects undergoing coronary angiography in two groups of non CAD (n=146) and CAD (n=196). -514C®T polymorphism was determined using polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP).Results: After adjustment for age, smoking and body mass index, HDL-Cholesterol concentrations were significantly higher in men with the C/T& T/T genotype than those with the C/C genotype (mean 38.6 and 34.7 respectively P=0.01). The frequency of T ALLELE in non CAD was 0.136 and 0.226 in female and male respectively and 0.170 and 0.223 for female and male in CAD subjects. There was no difference in T ALLELE frequency in CAD and none CAD groups in male and female (P=0.466 and 0.722 respectively).Conclusion: -514C®T of LIPC gene have a positive effect on HDL-C concentration especially in male gender. However, no difference was determined in frequency of T ALLELE between CAD and normal arteries subjects.

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APA: Copy

GHATREH SAMANI, K., NOORI, M., ROHBANI NOBAR, M., HASHEMZADEH CHALESHTORY, M., FARROKHI, E., & DARABI AMIN, M.. (2012). THE -514C/T POLYMORPHISM OF HEPATIC LIPASE GENE AMONG IRANIAN PATIENTS WITH CORONARY HEART DISEASE. IRANIAN JOURNAL OF PUBLIC HEALTH, 41(1), 59-65. SID. https://sid.ir/paper/272824/en

Vancouver: Copy

GHATREH SAMANI K., NOORI M., ROHBANI NOBAR M., HASHEMZADEH CHALESHTORY M., FARROKHI E., DARABI AMIN M.. THE -514C/T POLYMORPHISM OF HEPATIC LIPASE GENE AMONG IRANIAN PATIENTS WITH CORONARY HEART DISEASE. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2012;41(1):59-65. Available from: https://sid.ir/paper/272824/en

IEEE: Copy

K. GHATREH SAMANI, M. NOORI, M. ROHBANI NOBAR, M. HASHEMZADEH CHALESHTORY, E. FARROKHI, and M. DARABI AMIN, “THE -514C/T POLYMORPHISM OF HEPATIC LIPASE GENE AMONG IRANIAN PATIENTS WITH CORONARY HEART DISEASE,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 41, no. 1, pp. 59–65, 2012, [Online]. Available: https://sid.ir/paper/272824/en

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