مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

294
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

199
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

SERUM ADIPONECTIN AND RESISTIN LEVELS IN DE NOVO AND RELAPSED ACUTE LYMPHOBLASTIC LEUKEMIA CHILDREN PATIENTS

Pages

  504-510

Abstract

 Background: Adipose tissue secretes a large number of adipocytokines such as leptin, RESISTIN, and ADIPONECTIN. Many of these hormones and cytokines are altered in obese individuals and may lead to disruption of the normal balance between cell proliferation, differentiation, and apoptosis. The aim of our work was to investigate the disturbance of secretion of ADIPONECTIN and RESISTIN in de novo and relapsed ACUTE LYMPHOBLASTIC LEUKEMIA (ALL) in Egyptian children and determine whether ADIPONECTIN and RESISTIN are implicated in increased risk relapse compared to healthy individu-als.Methods: Measurements of ADIPONECTIN and RESISTIN were performed at diagnosis, in 32 patients with de novo ALL aged 3 to 18 years (mean 9.8 y) and 19 children with relapsed ALL aged 5 to 17 (mean 9.9 yr).10 apparently healthy children with matched age and sex were used as controls.Results: Mean ADIPONECTIN levels were low (P<0.05), whereas mean RESISTIN levels were high (P<0.05) at diagnosis and relapsed ALL (compared to healthy controls). A significant decrease of ADIPONECTIN levels was observed in re-lapsed ALL compared to de novo ALL. In contrast RESISTIN was significantly increased in relapsed ALL compared to de novo patients. ADIPONECTIN in ALL subjects inversely correlated with RESISTIN level (r=-0.51, P<0.001).Conclusion: Low ADIPONECTIN and high RESISTIN level at diagnosis suggest their implication in ALL pathogenesis and may serve as potential clinically significant diagnostic markers to detect leukemic relapse.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    A EL BAZ, HATIM, E MOSA, TAMER, M ELABD, ELHAM, RAMADAN, AMAL, S ELHAROUN, AHMED, A ELMORSY, ELSAYED, & I FOUDA, MANAL. (2013). SERUM ADIPONECTIN AND RESISTIN LEVELS IN DE NOVO AND RELAPSED ACUTE LYMPHOBLASTIC LEUKEMIA CHILDREN PATIENTS. IRANIAN JOURNAL OF PUBLIC HEALTH, 42(5), 504-510. SID. https://sid.ir/paper/273104/en

    Vancouver: Copy

    A EL BAZ HATIM, E MOSA TAMER, M ELABD ELHAM, RAMADAN AMAL, S ELHAROUN AHMED, A ELMORSY ELSAYED, I FOUDA MANAL. SERUM ADIPONECTIN AND RESISTIN LEVELS IN DE NOVO AND RELAPSED ACUTE LYMPHOBLASTIC LEUKEMIA CHILDREN PATIENTS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2013;42(5):504-510. Available from: https://sid.ir/paper/273104/en

    IEEE: Copy

    HATIM A EL BAZ, TAMER E MOSA, ELHAM M ELABD, AMAL RAMADAN, AHMED S ELHAROUN, ELSAYED A ELMORSY, and MANAL I FOUDA, “SERUM ADIPONECTIN AND RESISTIN LEVELS IN DE NOVO AND RELAPSED ACUTE LYMPHOBLASTIC LEUKEMIA CHILDREN PATIENTS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 42, no. 5, pp. 504–510, 2013, [Online]. Available: https://sid.ir/paper/273104/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button