THYROID AUTOIMMUNITY DISORDERS IN PATIENTS WITH CHRONIC HEPATITIS C, BEFORE INTERFERON THERAPY

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ALAVIAN S.M.; ASAARI SH.; MANZOURI JOUYBARI H.; MOHAMMADALIZADEH A.H.

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Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2006 | Volume:8 | Issue:1 (SN 29) Page(s): 17-23

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Title

THYROID AUTOIMMUNITY DISORDERS IN PATIENTS WITH CHRONIC HEPATITIS C, BEFORE INTERFERON THERAPY

Author(s)

ALAVIAN S.M. | ASAARI SH. | MANZOURI JOUYBARI H. | MOHAMMADALIZADEH A.H. | Issue Writer Certificate

Keywords

HEPATITIS CQ3

AUTOIMMUNITYQ3

THYROID DISORDERSQ3

ANTI THYROPEROXIDASE ANTIBODYQ3

ANTI THYROGLOBULIN ANTIBODYQ3

Abstract

Introduction: Several researchers believe that thyroid AUTOIMMUNITY is more prevalent in patients with HEPATITIS C than in the general population, however this is still a controversial issue. The aim of the current study was to determine 1) the frequency of thyroid autoantibodies, 2) the frequency of thyroid dysfunction, 3) correlation of thyroid autoantibodies and dysfunction with demographic and clinical variables, in patients with chronic HEPATITIS C. Materials and Methods: This cross-sectional study was conducted on 250 patients with chronic HEPATITIS C; patients were selected by simple non sampling from patients referring to the Tehran HEPATITIS Center in 2003 and 2004. Demographic data (age, sex, educational level, job) and clinical variables (including risk factors, liver enzymes, liver histopathology, HCV RNAviral load), were obtained. Anti Thyronin (TPO Ab, 124), Anti thyroglobulin (TG Ab, n=117), TSH (n=239), T3 (n=242), T4 (n=245), T3RU (n=134) was tested. Results: TPO Ab and TGAb were seen in 4% and 3.4% respectively. 1.2% had the history of thyroid diorders. 4 subjects had thyrotoxicosis, 1 subject had Hashimoto thyroiditis, 3 subjects had subclinical hyperthyroidisem, and 5 patients had subclinical hypothyroidisem. Positive TPO Ab had a statistical correlation that was marginally significant correlation with cirrhosis, physical symptoms and history of traditional phlebotomy (0.05<p<0.1). Positive TG Ab had statistical correlation that was marginally significant correlation with diabetes and blood transfusion (0.05<p<0.1). Positive TPO Ab or TG Ab was not significantly correlated with thyroid dysfunction. Conclusion: This study reported the relative frequency of thyroid autoantibodies in HEPATITIS C patients of our country to be 7%, which is in agreement with some previous studies.While this study did report some correlation with antithyroid antibodies and clinical variables in chronic HEPATITIS C, further studies in this field with a larger sample size is recommended.

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APA: Copy

ALAVIAN, S.M., ASAARI, SH., MANZOURI JOUYBARI, H., & MOHAMMADALIZADEH, A.H.. (2006). THYROID AUTOIMMUNITY DISORDERS IN PATIENTS WITH CHRONIC HEPATITIS C, BEFORE INTERFERON THERAPY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 8(1 (SN 29)), 17-23. SID. https://sid.ir/paper/27311/en

Vancouver: Copy

ALAVIAN S.M., ASAARI SH., MANZOURI JOUYBARI H., MOHAMMADALIZADEH A.H.. THYROID AUTOIMMUNITY DISORDERS IN PATIENTS WITH CHRONIC HEPATITIS C, BEFORE INTERFERON THERAPY. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2006;8(1 (SN 29)):17-23. Available from: https://sid.ir/paper/27311/en

IEEE: Copy

S.M. ALAVIAN, SH. ASAARI, H. MANZOURI JOUYBARI, and A.H. MOHAMMADALIZADEH, “THYROID AUTOIMMUNITY DISORDERS IN PATIENTS WITH CHRONIC HEPATITIS C, BEFORE INTERFERON THERAPY,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 8, no. 1 (SN 29), pp. 17–23, 2006, [Online]. Available: https://sid.ir/paper/27311/en

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