مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Information Journal Paper

Title

HAPLOTYPE FREQUENCY OF G691S/S904S IN THE RET PROTO-ONCOGENE IN PATIENTS WITH MEDULLARY THYROID CARCINOMA

Pages

  235-240

Abstract

 Background: MEDULLARY thyroid carcinoma (MTC) occurs in both sporadic (75%) and hereditary (25%) forms. The missense mutations of the REarranged during Transfection (RET) proto-oncogene in MTC development have been well demonstrated. The aim of this study was to investigate frequency of G691S/S904S HAPLOTYPE in MTC patients and their relatives.Methods: In this research 293 participants were studied, including 181 patients (102 female, 79 male) and 112 their relatives (58 female, 54 male). Genomic DNA was extracted from peripheral blood leucocytes using the standard Salting Out/Proteinase K method. Nucleotide change detection was performed using PCR and direct DNA sequencing methods.Results: According to DNA sequencing results, 159 individuals (104 patients, 55 relatives) had both G691S (rs1799939) missense mutation in exon11 and S904S (rs1800863) synonymous mutation in exon 15 of RET protooncogene. The allele frequency of G691S/S904S HAPLOTYPE was 21.15% in patients and 10.75% in their relatives.Conclusion: The obtained data showed the frequency of G691S/S904S RET gene haplotype among Iranian MTC patients and their relatives. The G691S and S904S nucleotide changes were in complete linkage disequilibrium, so the results were grouped together and referred to as G691S/S904S HAPLOTYPE. Further analysis is need to demonstrate the association between this haplotype and MTC development.

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    APA: Copy

    SHEIKHOLESLAMI, SARA, ZARIF YEGANEH, MARJAN, HOGHOOGHI RAD, LALEH, GOLAB GHADAKSAZ, HODA, & HEDAYATI, MEHDI. (2014). HAPLOTYPE FREQUENCY OF G691S/S904S IN THE RET PROTO-ONCOGENE IN PATIENTS WITH MEDULLARY THYROID CARCINOMA. IRANIAN JOURNAL OF PUBLIC HEALTH, 43(2), 235-240. SID. https://sid.ir/paper/273202/en

    Vancouver: Copy

    SHEIKHOLESLAMI SARA, ZARIF YEGANEH MARJAN, HOGHOOGHI RAD LALEH, GOLAB GHADAKSAZ HODA, HEDAYATI MEHDI. HAPLOTYPE FREQUENCY OF G691S/S904S IN THE RET PROTO-ONCOGENE IN PATIENTS WITH MEDULLARY THYROID CARCINOMA. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2014;43(2):235-240. Available from: https://sid.ir/paper/273202/en

    IEEE: Copy

    SARA SHEIKHOLESLAMI, MARJAN ZARIF YEGANEH, LALEH HOGHOOGHI RAD, HODA GOLAB GHADAKSAZ, and MEHDI HEDAYATI, “HAPLOTYPE FREQUENCY OF G691S/S904S IN THE RET PROTO-ONCOGENE IN PATIENTS WITH MEDULLARY THYROID CARCINOMA,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 43, no. 2, pp. 235–240, 2014, [Online]. Available: https://sid.ir/paper/273202/en

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