PROGNOSTIC SIGNIFICANCE OF VEGF-C EXPRESSION IN PATIENTS WITH BREAST CANCER: A META-ANALYSIS

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LIANG BIN; LI YUNHUI

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Public Health Year:2014 | Volume:43 | Issue:2 Page(s): 128-135

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Information Journal Paper

Title

PROGNOSTIC SIGNIFICANCE OF VEGF-C EXPRESSION IN PATIENTS WITH BREAST CANCER: A META-ANALYSIS

Author(s)

LIANG BIN | LI YUNHUI | Issue Writer Certificate

Keywords

BREAST CANCER

PROGNOSIS

META-ANALYSIS

VASCULAR ENDOTHELIAL GROWTH FACTOR-C

Abstract

Background: Vascular endothelial growth factor (VEGF)-C, as a lymphangiogenic factor, plays important roles in the progression of several malignancies. However, its clinical prognostic value in BREAST CANCER still remains controversial. We performed a META-ANALYSIS of available studies to assess the association between VEGF-C expression and the outcomes of BREAST CANCER patients.Methods: We searched eligible studies in three English databases (MEDLINE, EMBASE, and Web of Science) and two Chinese databases (Wanfang and Chinese National Knowledge Infrastructure databases). key word used in the research included "VEGF-C", "BREAST CANCER", "immunohistochemistry", "breast neoplasma (s) ", "breast carcinoma", "metastasis", and "prognosis". Fourteen studies with a total of 1, 573 BREAST CANCER cases were finally included into the META-ANALYSIS. The pooled odds ratios (ORs) with the corresponding 95% confidence interval (95% CIs) for lymph node metastasis, overall survival, and disease-free survival were calculated by using fixed-effects or random-effects models. Heterogeneity and publication bias were also assessed.Results: META-ANALYSIS of random-effects model showed VEGF-C expression was associated with lymph node metastasis in patients with BREAST CANCER (random-effects, OR=2.14; 95 % CI 1.21–3.77, P=0.009). VEGF-C expression was associated with poorer overall survival (fixed-effects, OR=2.46, 95% CI: 1.46–4.14, P<0.001) and disease-free survival (fixed-effects, OR=2.10, 95% CI: 1.32–3.35, P=0.002) in patients with BREAST CANCER.Conclusion: VEGF-C expression is positively associated with lymph node metastasis in BREAST CANCER, and VEGF-C detection in BREAST CANCER might be an effective and feasible means to predict outcome.

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APA: Copy

LIANG, BIN, & LI, YUNHUI. (2014). PROGNOSTIC SIGNIFICANCE OF VEGF-C EXPRESSION IN PATIENTS WITH BREAST CANCER: A META-ANALYSIS. IRANIAN JOURNAL OF PUBLIC HEALTH, 43(2), 128-135. SID. https://sid.ir/paper/273209/en

Vancouver: Copy

LIANG BIN, LI YUNHUI. PROGNOSTIC SIGNIFICANCE OF VEGF-C EXPRESSION IN PATIENTS WITH BREAST CANCER: A META-ANALYSIS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2014;43(2):128-135. Available from: https://sid.ir/paper/273209/en

IEEE: Copy

BIN LIANG, and YUNHUI LI, “PROGNOSTIC SIGNIFICANCE OF VEGF-C EXPRESSION IN PATIENTS WITH BREAST CANCER: A META-ANALYSIS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 43, no. 2, pp. 128–135, 2014, [Online]. Available: https://sid.ir/paper/273209/en

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