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Information Journal Paper

Title

RELATIONSHIP BETWEEN CATSPERB, NR5A2 GENE POLYMORPHISMS AND PEAK BONE MINERAL DENSITY IN COLLEGE STUDENTS IN CHINA

Pages

  1060-1069

Keywords

PEAK BONE MINERAL DENSITY (PBMD) 

Abstract

 Background: Peak bone mineral density (PBMD) is influenced by both genetic and environmental factors, genes explains most of variation. As the novel candidate genes CATSPERB and NR5A2 may have been associated with spinal PBMD in adult. This study was to investigate the relationship among these two genes PBMD and the life style factors in young female.Methods: The rs1298989 single nucleotide polymorphism (SNP) of the CATSPERB gene and the RS3762397 SNP of the NR5A2 gene were genotyped using SNaPshot® in 359 students from Xinjiang. The prospective study included 203 Han and 156 Uyghur subjects. PBMD was measured using quantitative computed tomography (QCT). Calcium, phosphate and alkaline phosphatase were measured by ELISA method. Physical activity, dietary calcium and LIFE STYLES were assessed by questionnaire.Results: Both SNPs showed differences in genotype and allele frequencies (P<0.05) between the Han and Uyghur subjects. Total calcium intake, energy intake, tea and milk intake were also significantly different between two groups (P<0.05). Multiple regression analysis showed an association between PBMD and vitamin D intake (P= 0.000), milk (P=0.000), exercise (P=0.029), rs1298989 (P=0.028), energy intake (P=0.043).Conclusion: This study demonstrated the polymorphisms of the rs1298989 and RS3762397 are associated with PBMD both in Han and Uyghur subjects. PBMD, in Xinjiang, appears to be associated with several known factors that are well described in the literature. While the genotypes of rs1298989 and RS3762397 do not appear have a strong effect on the PBMD.

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    • Cite

    APA: Copy

    ZHAO, YUAN, LIU, WENYA, HUA, MA, SHI, RAONI, WANG, HAITAO, & YANG, WEN. (2014). RELATIONSHIP BETWEEN CATSPERB, NR5A2 GENE POLYMORPHISMS AND PEAK BONE MINERAL DENSITY IN COLLEGE STUDENTS IN CHINA. IRANIAN JOURNAL OF PUBLIC HEALTH, 43(8), 1060-1069. SID. https://sid.ir/paper/273370/en

    Vancouver: Copy

    ZHAO YUAN, LIU WENYA, HUA MA, SHI RAONI, WANG HAITAO, YANG WEN. RELATIONSHIP BETWEEN CATSPERB, NR5A2 GENE POLYMORPHISMS AND PEAK BONE MINERAL DENSITY IN COLLEGE STUDENTS IN CHINA. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2014;43(8):1060-1069. Available from: https://sid.ir/paper/273370/en

    IEEE: Copy

    YUAN ZHAO, WENYA LIU, MA HUA, RAONI SHI, HAITAO WANG, and WEN YANG, “RELATIONSHIP BETWEEN CATSPERB, NR5A2 GENE POLYMORPHISMS AND PEAK BONE MINERAL DENSITY IN COLLEGE STUDENTS IN CHINA,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 43, no. 8, pp. 1060–1069, 2014, [Online]. Available: https://sid.ir/paper/273370/en

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