RELATIONSHIP BETWEEN SERUM ZINC AND LEPTIN CONCENTRATIONS IN POSTMENOPAUSAL DIABETIC WOMEN

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TAGHDIR M.; JALALI MAHMOUD; JAZAYERI SEYED ABOU ALGHASEM; ASHOURPOUR M.; SEPANDI M.

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2010 | Volume:11 | Issue:6 (SN 48) Page(s): 656-660

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Title

RELATIONSHIP BETWEEN SERUM ZINC AND LEPTIN CONCENTRATIONS IN POSTMENOPAUSAL DIABETIC WOMEN

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Keywords

LEPTINQ2

ZNQ3

TYPE 2 DIABETES MELLITUSQ2

POSTMENOPAUSAL WOMENQ2

Abstract

Introduction: LEPTIN, a hormone secreted by the adipocytes, plays a key role in a feedback loop that maintains energy balance by signaling the state of energy stores to the brain and by influencing the regulation of appetite and energy metabolism. Zinc (Zn) also plays an important role in appetite regulation. It has been shown that ZN deficiency decreases appetite and that ZN supplementation increases it. Our aim is to evaluate the relationship between serum ZN, and LEPTIN in postmenopausal diabetic women.Materials and Methods: We studied 45 diabetic women and 45 healthy women (controls) with Body Mass Index (BMI) 25-30 kg/m2 and age 45-60 y. Serum LEPTIN, serum zinc, Tumor Necrosis Factor-a (TNF-a), and Interleukin-6 (IL-6) were determined in diabetic and healthy groups. Comparisons were performed with the t test in diabetic and healthy groups.Linear regression was used to evaluate the relations among different variables in the two groups.Results: There was a non-significant, negative correlation between serum LEPTIN and zinc in postmenopausal diabetic women (r=-0.14), and, a non-significant, positive correlation between serum LEPTIN and zinc in postmenopausal healthy women (r=0.10). TNF-a and IL-6 have no significant effects on the relationship between serum zinc and LEPTIN in postmenopausal diabetic and healthy women.Conclusion: There was no significant relationship between serum LEPTIN and zinc in postmenopausal diabetic women. The pathophysiological pathways by which zinc and LEPTIN regulate energy intake and appetite and the detailed mechanism between them need to be further clarified by future studies.

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APA: Copy

TAGHDIR, M., JALALI, MAHMOUD, JAZAYERI, SEYED ABOU ALGHASEM, ASHOURPOUR, M., & SEPANDI, M.. (2010). RELATIONSHIP BETWEEN SERUM ZINC AND LEPTIN CONCENTRATIONS IN POSTMENOPAUSAL DIABETIC WOMEN. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 11(6 (SN 48)), 656-660. SID. https://sid.ir/paper/27357/en

Vancouver: Copy

TAGHDIR M., JALALI MAHMOUD, JAZAYERI SEYED ABOU ALGHASEM, ASHOURPOUR M., SEPANDI M.. RELATIONSHIP BETWEEN SERUM ZINC AND LEPTIN CONCENTRATIONS IN POSTMENOPAUSAL DIABETIC WOMEN. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2010;11(6 (SN 48)):656-660. Available from: https://sid.ir/paper/27357/en

IEEE: Copy

M. TAGHDIR, MAHMOUD JALALI, SEYED ABOU ALGHASEM JAZAYERI, M. ASHOURPOUR, and M. SEPANDI, “RELATIONSHIP BETWEEN SERUM ZINC AND LEPTIN CONCENTRATIONS IN POSTMENOPAUSAL DIABETIC WOMEN,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 11, no. 6 (SN 48), pp. 656–660, 2010, [Online]. Available: https://sid.ir/paper/27357/en

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