ASSOCIATION OF G-2548A POLYMORPHISM IN THE PROMOTER OF LEPTIN GENE WITH PLASMA LEPTIN LEVEL AND RISK OF TYPE 2 DIABETES

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KOHAN L.; NASIRI M.; HABIB A.; BOLHASANI A.

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Journal: Journal of Shahid Sadoughi University of Medical Sciences Year:2013 | Volume:21 | Issue:1 (90) Page(s): 70-77

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Title

ASSOCIATION OF G-2548A POLYMORPHISM IN THE PROMOTER OF LEPTIN GENE WITH PLASMA LEPTIN LEVEL AND RISK OF TYPE 2 DIABETES

Author(s)

KOHAN L. | NASIRI M. | HABIB A. | BOLHASANI A. | Issue Writer Certificate

Keywords

LEPTINQ2

POLYMORPHISMQ2

PROMOTERQ2

TYPE 2 DIABETESQ2

Abstract

Introduction: LEPTIN, the obese (ob) gene product, is a cytokine-like hormone secreted mainly from adipose tissue; acting on a receptor site in the hypothalamus to inhibit food intake and stimulate energy expenditure. A G-2548G POLYMORPHISM in the LEPTIN gene PROMOTER has a strong influence on LEPTIN gene expression and adipose tissue secretion. The aim of this study was to examine the association of the LEPTIN G-2548A PROMOTER POLYMORPHISM with LEPTIN plasma level and susceptibility to TYPE 2 DIABETES.Methods: 100 patients with TYPE 2 DIABETES mellitus and 100 healthy controls were screened for the presence of G-2548A POLYMORPHISM using PCR-RFLP analysis. Body mass index, fasting LEPTIN and fasting glucose were also determined.Results: Carriers with the GG genotype (20.02±5.6mg/L) had significantly (P<0.001) higher LEPTIN levels than those with the AG genotypes (16.2±5.4mg/L) and AA genotypes (13.42±6.3). Also, LEP -2548GG genotype presented an increased risk of TYPE 2 DIABETES (OR: 3.26, 95%CI: 1.5-7.2, P=0.004). In the other words, GG genotypes in the region of -2548 are associated with increased risk of TYPE 2 DIABETES.Conclusion: The present study showed that G-2548A LEP POLYMORPHISM is important in regulating LEPTIN plasma level and is associated with risk of TYPE 2 DIABETES. Thus, this POLYMORPHISM may act as a molecular marker for TYPE 2 DIABETES.

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APA: Copy

KOHAN, L., NASIRI, M., HABIB, A., & BOLHASANI, A.. (2013). ASSOCIATION OF G-2548A POLYMORPHISM IN THE PROMOTER OF LEPTIN GENE WITH PLASMA LEPTIN LEVEL AND RISK OF TYPE 2 DIABETES. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, 21(1 (90)), 70-77. SID. https://sid.ir/paper/36302/en

Vancouver: Copy

KOHAN L., NASIRI M., HABIB A., BOLHASANI A.. ASSOCIATION OF G-2548A POLYMORPHISM IN THE PROMOTER OF LEPTIN GENE WITH PLASMA LEPTIN LEVEL AND RISK OF TYPE 2 DIABETES. JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES[Internet]. 2013;21(1 (90)):70-77. Available from: https://sid.ir/paper/36302/en

IEEE: Copy

L. KOHAN, M. NASIRI, A. HABIB, and A. BOLHASANI, “ASSOCIATION OF G-2548A POLYMORPHISM IN THE PROMOTER OF LEPTIN GENE WITH PLASMA LEPTIN LEVEL AND RISK OF TYPE 2 DIABETES,” JOURNAL OF SHAHID SADOUGHI UNIVERSITY OF MEDICAL SCIENCES, vol. 21, no. 1 (90), pp. 70–77, 2013, [Online]. Available: https://sid.ir/paper/36302/en

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