INVESTIGATION ON THE LEVELS OF IGF-I RECEPTOR AND IGF-I BINDING PROTEIN I IN THE BRAIN OF INSULIN RESISTANT RATS

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PARVANEH TAFRESHI A.; JALAL R.; DARVISH ALIPOUR SH.; SEPEHRI HOURI; ADELI K.

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2010 | Volume:11 | Issue:6 (SN 48) Page(s): 707-712

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Title

INVESTIGATION ON THE LEVELS OF IGF-I RECEPTOR AND IGF-I BINDING PROTEIN I IN THE BRAIN OF INSULIN RESISTANT RATS

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Keywords

DIABETES TYPE IIQ2

INSULIN RESISTANCEQ2

BRAINQ2

IGF BINDING PROTEIN IQ3

IGF-I RECEPTORQ3

Abstract

Introduction: There is limited knowledge available on the metabolism of glucose in the BRAIN, an insulin insensitive organ. Insulin receptors hybridize with insulin like growth factor receptor (IGF-I) to transduce the signals in different areas of the BRAIN. In this article we aimed at investigating whether the expression of IGF-I RECEPTOR and IGF-I binding proteins (IGFBP1) is changed in the BRAIN of the diabetic animal model.Materials and Methods: To induce INSULIN RESISTANCE, adult waster rats were fed with fructose in their drinking water (10%). The expression of IGF-I RECEPTOR and its binding protein were examined immunohistochemically.Results: Our findings demonstrated that the expression of IGF-I RECEPTOR and IGF-I binding protein were not changed in different areas of the BRAIN in insulin resistant rats, compared to those in the control rats.Conclusion: The unchanged expression levels of IGF-I RECEPTOR and its binding protein I not imply the lack of involvement of the IGF-I signal transduction pathway in the insulin resistant BRAIN, further investigations are to clarify the issue.

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APA: Copy

PARVANEH TAFRESHI, A., JALAL, R., DARVISH ALIPOUR, SH., SEPEHRI, HOURI, & ADELI, K.. (2010). INVESTIGATION ON THE LEVELS OF IGF-I RECEPTOR AND IGF-I BINDING PROTEIN I IN THE BRAIN OF INSULIN RESISTANT RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 11(6 (SN 48)), 707-712. SID. https://sid.ir/paper/27368/en

Vancouver: Copy

PARVANEH TAFRESHI A., JALAL R., DARVISH ALIPOUR SH., SEPEHRI HOURI, ADELI K.. INVESTIGATION ON THE LEVELS OF IGF-I RECEPTOR AND IGF-I BINDING PROTEIN I IN THE BRAIN OF INSULIN RESISTANT RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2010;11(6 (SN 48)):707-712. Available from: https://sid.ir/paper/27368/en

IEEE: Copy

A. PARVANEH TAFRESHI, R. JALAL, SH. DARVISH ALIPOUR, HOURI SEPEHRI, and K. ADELI, “INVESTIGATION ON THE LEVELS OF IGF-I RECEPTOR AND IGF-I BINDING PROTEIN I IN THE BRAIN OF INSULIN RESISTANT RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 11, no. 6 (SN 48), pp. 707–712, 2010, [Online]. Available: https://sid.ir/paper/27368/en

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