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Information Journal Paper

Title

PREDICTIVE POWER OF ETRE POLYMORPHISM AND KATG463 MUTATION TO INH-RESISTANCE OF M.TUBERCULOSIS (SHORT COMMUNICATION)

Pages

  263-268

Abstract

 Background: The MIRU-VNTR polymorphism and KATG463 mutation are used to genotype the mycobacterium tuberculosis, but the correlation between them and INH-resistance were unknown. This study was aimed to explore whether ETRE polymorphism and KATG463 mutation could predict the INH-resistance, and the relationship between ETRE polymorphism and KATG463 mutation.Methods: The ETRE, KATG463 mutation and DRUG RESISTANCE information of 109 M. tuberculosis strains were collected from online public database. We constructed the predictive diagnostic tool of ETRE polymorphism and KATG463 mutation. Chi-square test was used to analyze the relationship between ETRE polymorphism, KATG463 mutation and INH-resistance. ROC curve analysis and Z-test were used to evaluate the predictive ability of ETRE and KATG463. The relationship between ETRE polymorphism and KATG463 mutation was analyzed with Spearman correlation analysis.Results: The mutation rate of KATG463 was 27.50%, and the h value of ETRE polymorphism was 0.67. KATG463 mutation was associated with INH resistance (OR=3.72). The INH DRUG RESISTANCE rate in VNTR³5 group was 3.43 times higher than that in VNTR£3 group (c2=24.77, P<0.01), and there was no significant difference of INH resistance between the VNTR=4 group and VNTR£3 group. The areas under the ROC curve of two loci prediction diagnostic tools were 0.64 and 0.70 respectively. The KATG463 mutation was significantly related to the ETRE poly-morphismr (r=0.79, P<0.01).Conclusion: Both KATG463 mutation and the ETRE polymorphism can predict the INH-resistance of tuberculosis. The KATG463 mutation was associated with ETRE VNTR polymorphism.

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    Cite

    APA: Copy

    WEN, YU FENG, JIANG, CHAO, CHENG, XIAN FENG, ZHANG, ZHI PING, CHEN, BAI FENG, & ZHU, YU. (2015). PREDICTIVE POWER OF ETRE POLYMORPHISM AND KATG463 MUTATION TO INH-RESISTANCE OF M.TUBERCULOSIS (SHORT COMMUNICATION). IRANIAN JOURNAL OF PUBLIC HEALTH, 44(2), 263-268. SID. https://sid.ir/paper/273709/en

    Vancouver: Copy

    WEN YU FENG, JIANG CHAO, CHENG XIAN FENG, ZHANG ZHI PING, CHEN BAI FENG, ZHU YU. PREDICTIVE POWER OF ETRE POLYMORPHISM AND KATG463 MUTATION TO INH-RESISTANCE OF M.TUBERCULOSIS (SHORT COMMUNICATION). IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2015;44(2):263-268. Available from: https://sid.ir/paper/273709/en

    IEEE: Copy

    YU FENG WEN, CHAO JIANG, XIAN FENG CHENG, ZHI PING ZHANG, BAI FENG CHEN, and YU ZHU, “PREDICTIVE POWER OF ETRE POLYMORPHISM AND KATG463 MUTATION TO INH-RESISTANCE OF M.TUBERCULOSIS (SHORT COMMUNICATION),” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 44, no. 2, pp. 263–268, 2015, [Online]. Available: https://sid.ir/paper/273709/en

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