POTENTIAL PREDICTORS FOR SEROFAST STATE AFTER TREATMENT AMONG HIV-NEGATIVE PERSONS WITH SYPHILIS IN CHINA: A SYSTEMATIC REVIEW AND META-ANALYSIS

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QIN JIABI; YANG TUBAO; WANG HUA; FENG TIEJIAN; LIU XIAOYING

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

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Journal: Iranian Journal of Public Health Year:2015 | Volume:44 | Issue:2 Page(s): 155-169

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Title

POTENTIAL PREDICTORS FOR SEROFAST STATE AFTER TREATMENT AMONG HIV-NEGATIVE PERSONS WITH SYPHILIS IN CHINA: A SYSTEMATIC REVIEW AND META-ANALYSIS

Author(s)

Keywords

SYPHILIS

SEROFAST

T-LYMPHOCYTE SUBSET

INTERLEUKIN

CHINA

META-ANALYSIS

Abstract

Background: Several studies have been conducted in CHINA in order to investigate the potential predictors of SEROFAST state after treatment among syphilitic patients. However, there is a remarkable diversity among the results. This META-ANALYSIS was conducted to assess potential predictors of SEROFAST among syphilitic patients in CHINA.Methods: International and national electronic databases were searched up to September 2013. Reference lists of re-trieved articles were also reviewed. Cohort or case-control studies addressing risk factors of SEROFAST among syphilitic patients were included in this study.Results: We assessed 27 separate studies involving overall 6682 HIV-negative participants with SYPHILIS of which 1962 remained in the SEROFAST state. The SEROFAST was positively associated with older age (Ptrend=0.001), female (summary risk ratio [sRR]=1.50, 95%CI: 1.34-1.68), latent SYPHILIS (sRRlatent vs primary=3.17, 95%CI: 2.66-3.77; sRRlatent vs secondary=2.00, 95%CI: 1.48-2.69) as well as non-penicillin treatment (sRR=2.99, 95%CI: 2.45-3.67), but negatively associated with higher baseline titers (sRR>1: 32 vs ≤1: 32=0.63, 95%CI: 0.54-0.75). Compared with healthy group and serological cure group, respectively, the levels of CD4 (+), IL-2, and IL-6 among SEROFAST patients were decreased (standardized mean difference [SMD]<0, P<0.05), but the levels of CD8 (+) and IL-10 were increased (SMD>0, P<0.05). Some studies also hinted the SEROFAST was associated with subtypes i of treponema pallidum (TP) repeat gene (RR i vs d=4.67, 95%CI: 1.31-16.69) and TP occult infection.Conclusion: The age, gender, stage of infection, baseline titers, treatment drug, cellular immune suppression and dis-orders, TP occult infection and subtypes i of TP repeat gene should be considered as important predictors of SEROFAST. However, until now the definition and mechanism of SEROFAST has still been not clear.

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APA: Copy

QIN, JIABI, YANG, TUBAO, WANG, HUA, FENG, TIEJIAN, & LIU, XIAOYING. (2015). POTENTIAL PREDICTORS FOR SEROFAST STATE AFTER TREATMENT AMONG HIV-NEGATIVE PERSONS WITH SYPHILIS IN CHINA: A SYSTEMATIC REVIEW AND META-ANALYSIS. IRANIAN JOURNAL OF PUBLIC HEALTH, 44(2), 155-169. SID. https://sid.ir/paper/273721/en

Vancouver: Copy

QIN JIABI, YANG TUBAO, WANG HUA, FENG TIEJIAN, LIU XIAOYING. POTENTIAL PREDICTORS FOR SEROFAST STATE AFTER TREATMENT AMONG HIV-NEGATIVE PERSONS WITH SYPHILIS IN CHINA: A SYSTEMATIC REVIEW AND META-ANALYSIS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2015;44(2):155-169. Available from: https://sid.ir/paper/273721/en

IEEE: Copy

JIABI QIN, TUBAO YANG, HUA WANG, TIEJIAN FENG, and XIAOYING LIU, “POTENTIAL PREDICTORS FOR SEROFAST STATE AFTER TREATMENT AMONG HIV-NEGATIVE PERSONS WITH SYPHILIS IN CHINA: A SYSTEMATIC REVIEW AND META-ANALYSIS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 44, no. 2, pp. 155–169, 2015, [Online]. Available: https://sid.ir/paper/273721/en

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