THE CD4+/CD8+ RATIO IN PULMONARY TUBERCULOSIS: SYSTEMATIC AND META-ANALYSIS ARTICLE (REVIEW ARTICLE)

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YIN YONGMEI; QIN JIE; DAI YAPING; ZENG FANWEI; PEI HAO; WANG JUN

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Journal: Iranian Journal of Public Health Year:2015 | Volume:44 | Issue:2 Page(s): 185-193

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Title

THE CD4+/CD8+ RATIO IN PULMONARY TUBERCULOSIS: SYSTEMATIC AND META-ANALYSIS ARTICLE (REVIEW ARTICLE)

Author(s)

Keywords

PULMONARY TUBERCULOSIS

CD4+/CD8+RATIO

META-ANALYSIS

Abstract

Background: The ratio of CD4+/CD8+has been used as a clinically index to evaluate patients’ immunity. Numerous researchers have studied CD4+/CD8+ratio in PULMONARY TUBERCULOSIS (PTB) patients. However, the change of CD4+/CD8+ratio remains controversial. We present a META-ANALYSIS of 15 case-control studies to identify the change of CD4+/CD8+ratio in PTB patients.Methods: We assessed heterogeneity of effect estimates within each group using I2 test. Subgroup analysis was per-formed to explore the potential source of heterogeneity. To investigate further the potential publication bias, we visu-ally examined the funnel plots. For robustness of results, we performed sensitivity analysis by removing studies. Data entry and analyses were carried out with RevMan 5.2 (The Nordic Cochrane Centre).Results: Twelve peripheral blood studies were categorized into two subgroups. Eight studies presented a significant decrease of CD4+/CD8+ratio in PTB cases compared to healthy subjects (SMD: -0.45; 95% CI -0.65–-0.25; I2=7%). Other four studies researched on the newly diagnosed patients presented a more seriously and significantly de-crease (SMD: -2.17; 95% CI -2.61–-1.74; I2=37%). The pooled analysis of bronchoalveolar lavage fluid (BALF) studies showed a significant increase of CD4+/CD8+ratio using Flow Cytometry (FCM) (SMD: 4.75; 95% CI 3.44–6.05; I2=0%).Conclusion: The present META-ANALYSIS indicated that there was a synthetic evidence for the reduced CD4+/CD8+ratio in peripheral blood of PTB patients, especially newly diagnosed cases. However, the CD4+/CD8+ratio in BALF was increased using method of FCM.

Cites

BRONCHOALVEOLAR LAVAGE FLUID CHARACTERISTICS OF PATIENTS WITH SARCOIDOSIS AND NONSARCOIDOSIS INTERSTITIAL LUNG DISEASES: TEN-YEAR EXPERIENCE OF A SINGLE CENTER IN TURKEY

References

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APA: Copy

YIN, YONGMEI, QIN, JIE, DAI, YAPING, ZENG, FANWEI, PEI, HAO, & WANG, JUN. (2015). THE CD4+/CD8+ RATIO IN PULMONARY TUBERCULOSIS: SYSTEMATIC AND META-ANALYSIS ARTICLE (REVIEW ARTICLE). IRANIAN JOURNAL OF PUBLIC HEALTH, 44(2), 185-193. SID. https://sid.ir/paper/273723/en

Vancouver: Copy

YIN YONGMEI, QIN JIE, DAI YAPING, ZENG FANWEI, PEI HAO, WANG JUN. THE CD4+/CD8+ RATIO IN PULMONARY TUBERCULOSIS: SYSTEMATIC AND META-ANALYSIS ARTICLE (REVIEW ARTICLE). IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2015;44(2):185-193. Available from: https://sid.ir/paper/273723/en

IEEE: Copy

YONGMEI YIN, JIE QIN, YAPING DAI, FANWEI ZENG, HAO PEI, and JUN WANG, “THE CD4+/CD8+ RATIO IN PULMONARY TUBERCULOSIS: SYSTEMATIC AND META-ANALYSIS ARTICLE (REVIEW ARTICLE),” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 44, no. 2, pp. 185–193, 2015, [Online]. Available: https://sid.ir/paper/273723/en

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