IMMUNOPHENOTYPIC CHARACTERIZATION OF PERIPHERAL BLOOD T-LYMPHOCYTES AND THEIR SUBPOPULATIONS IN TUBERCULOSIS PATIENTS BEFORE AND AFTER TREATMENTS

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PESSARAN Z.; SAHEB FOSOUL F.; OREYZI F.; GHAVAMI NEZHAD A.; KIANI A.; DANA SIADAT D.

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Journal Paper

Paper Information

Journal: Iranian Journal of Allergy, Asthma and Immunology Year:2005 | Volume:4 | Issue:1 Page(s): 23-26

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Title

IMMUNOPHENOTYPIC CHARACTERIZATION OF PERIPHERAL BLOOD T-LYMPHOCYTES AND THEIR SUBPOPULATIONS IN TUBERCULOSIS PATIENTS BEFORE AND AFTER TREATMENTS

Author(s)

Keywords

CELL MEDIATED IMMUNITY

IMMUNOPHENOTYPING

T LYMPHOCYTES

TUBERCULOSIS

Abstract

Tuberculosis is a chronic mycobacterial infection. The main effector cells against mycobacterium TUBERCULOSIS are CD4+ T LYMPHOCYTES. Our objective in this research was to evaluate the quantity of T LYMPHOCYTES and their subpopulations before and after treatments with combination of 4 drugs (Rifampcin, Isoniaside, pyrasinamide, Ethambutal) for 2 months directly in sputum-positive TUBERCULOSIS patients. Twenty patients as cases and twenty healthy people were selected as controls. Flow cytometry was used for TCD3+, TCD4+ and TCD8+ lymphocytes by using monoclonal antibodies. Our results indicated that there was alteration in CELL MEDIATED IMMUNITY during TUBERCULOSIS showing itself as decrease in TCD3+ and TCD4+ lymphocytes and increase in TCD8+ lymphocytes. The changes in TCD3+ and TCD4+ but not in TCD8+ were reversible after 2 months of treatment.

Cites

THE CD4+/CD8+ RATIO IN PULMONARY TUBERCULOSIS: SYSTEMATIC AND META-ANALYSIS ARTICLE (REVIEW ARTICLE)

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APA: Copy

PESSARAN, Z., SAHEB FOSOUL, F., OREYZI, F., GHAVAMI NEZHAD, A., KIANI, A., & DANA SIADAT, D.. (2005). IMMUNOPHENOTYPIC CHARACTERIZATION OF PERIPHERAL BLOOD T-LYMPHOCYTES AND THEIR SUBPOPULATIONS IN TUBERCULOSIS PATIENTS BEFORE AND AFTER TREATMENTS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), 4(1), 23-26. SID. https://sid.ir/paper/291080/en

Vancouver: Copy

PESSARAN Z., SAHEB FOSOUL F., OREYZI F., GHAVAMI NEZHAD A., KIANI A., DANA SIADAT D.. IMMUNOPHENOTYPIC CHARACTERIZATION OF PERIPHERAL BLOOD T-LYMPHOCYTES AND THEIR SUBPOPULATIONS IN TUBERCULOSIS PATIENTS BEFORE AND AFTER TREATMENTS. IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI)[Internet]. 2005;4(1):23-26. Available from: https://sid.ir/paper/291080/en

IEEE: Copy

Z. PESSARAN, F. SAHEB FOSOUL, F. OREYZI, A. GHAVAMI NEZHAD, A. KIANI, and D. DANA SIADAT, “IMMUNOPHENOTYPIC CHARACTERIZATION OF PERIPHERAL BLOOD T-LYMPHOCYTES AND THEIR SUBPOPULATIONS IN TUBERCULOSIS PATIENTS BEFORE AND AFTER TREATMENTS,” IRANIAN JOURNAL OF ALLERGY, ASTHMA AND IMMUNOLOGY (IJAAI), vol. 4, no. 1, pp. 23–26, 2005, [Online]. Available: https://sid.ir/paper/291080/en

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