EFFECT OF MELATONIN ON SEXUAL BEHAVIOR IN MALE DIABETIC RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

BABAEI F.; HEYDARI REZA; ILKHANIPOUR M.; AZIZI SAEID

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2009 | Volume:11 | Issue:2 (SN 44) Page(s): 199-207

Download Full-Text

Persian Verion

View:

2,569

Download:

Cites:

Information Journal Paper

Title

EFFECT OF MELATONIN ON SEXUAL BEHAVIOR IN MALE DIABETIC RATS

Author(s)

BABAEI F. | HEYDARI REZA | ILKHANIPOUR M. | AZIZI SAEID | Issue Writer Certificate

Keywords

DIABETESQ3

MELATONINQ2

SEXUAL BEHAVIORQ2

WDSQ3

5-HT2AQ3

SEROTONERGIC SYSTEMQ3

Abstract

Introduction: Several clinical studies indicate deterioration of SEXUAL BEHAVIOR in diabetic patients. The pathophysiological mechanisms of diabetic sexual impotence remain obscure. In this study the therapeutic effects of melatonin on SEXUAL BEHAVIOR were investigated through the central serotonergic system in diabetic rats. Materials and Methods: In this study, 30 male adult Wistar rats, weighing 200±20 g, were used. Animals were divided into three groups, the controls (C), diabetic (D) and the melatonin-treated diabetic (M) group. Experimental DIABETES was induced by intraperitoneal injection of 50 mg/kg streptozotocin. Melatonin was injected (10 mg/kg i. p. ) after 3 days of streptozotocin injection for 30 days. At the end of the administration period, the SEXUAL BEHAVIOR of each male rat to an ovariectomized female rat was assessed for 40 min. Serotonergic type 2 (5-HT2A) receptor activities were investigated through spontaneous WDS behavior, and experimental data were statistically analyzed. Results: First mount, first intromission and first ejaculation latencies significantly (p<0. 05) increased in diabetic rats as compared to controls. Melatonin treatment significantly (p<0. 05) reduced these responses in the M group, compared to the D one. Also the number of mounts, intromissions and ejaculations significantly (p<0. 05) decreased in diabetic rats compared to controls. Administration of melatonin significantly (p<0. 05) increased these activities in the M group as compared to the D one. Calculation of copulatory efficiency and the sexual activity index of each rat indicate that reproductive activity in diabetic rats was significantly (p<0. 05) less than other two groups. The number of WDS responses was significantly (p<0. 05) different in all three groups. Conclusion: Sexual dysfunction in diabetic animals was accompanied by decreasing of 5-HT2A receptor activities, and melatonin prevented the DIABETES-induced sexual impotence by modulating of central serotonergic system activity.

Cites

No record.

References

No record.

Cite

APA: Copy

BABAEI, F., HEYDARI, REZA, ILKHANIPOUR, M., & AZIZI, SAEID. (2009). EFFECT OF MELATONIN ON SEXUAL BEHAVIOR IN MALE DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 11(2 (SN 44)), 199-207. SID. https://sid.ir/paper/27380/en

Vancouver: Copy

BABAEI F., HEYDARI REZA, ILKHANIPOUR M., AZIZI SAEID. EFFECT OF MELATONIN ON SEXUAL BEHAVIOR IN MALE DIABETIC RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2009;11(2 (SN 44)):199-207. Available from: https://sid.ir/paper/27380/en

IEEE: Copy

F. BABAEI, REZA HEYDARI, M. ILKHANIPOUR, and SAEID AZIZI, “EFFECT OF MELATONIN ON SEXUAL BEHAVIOR IN MALE DIABETIC RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 11, no. 2 (SN 44), pp. 199–207, 2009, [Online]. Available: https://sid.ir/paper/27380/en

Related Journal Papers