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Information Journal Paper

Title

CARDIOPROTECTIVE EFFECT OF HIGH INTENSITY INTERVAL TRAINING AND NITRIC OXIDE METABOLITES (NO2-, NO3-)

Pages

  1270-1276

Abstract

 Background: The aim of this study was to investigate the effects of HIGH-INTENSITY INTERVAL TRAINING (HIIT) on nitric oxide metabolites (NO2-, NO3-) and myocardial infarct size after Ischemia/Reperfusion (I/R) injury in healthy male rats.Methods: A total of 44 Wistar rats were randomly divided into 4 groups including HIIT (n=8), HIIT+IR protocol (n=14), control (n=8), and control+IR (n=14). Each training session of HIIT consisted of 1 hour of exercise in three stages: 6-minute running at 50-60% VO2max for warm-up; 7 intervals of 7-minute running on treadmill with a slope of 50 to 20° (4 minutes with an intensity of 80-100% VO2max and 3 minutes at 50-60% VO2max); and 5-minute running at 50-60% VO2max for cool-down. The control group did NOt participate in any exercise program. Nitric Oxide (NO) and its metabolites were measured by using Griess reaction test.Results: The results showed that eight weeks of exercise training exerted a significantly increasing effect on nitrite (8.55 mmol per liter, equivalent to 34.79%), nitrate (62.02 mmol per liter, equivalent to 149.48%), and NOx (66 mmol per liter, equivalent to 98.11%) in the HIIT group compared with the control group. The results showed myocardial infract size (IS) was significantly smaller (23.2%, P<0.001) in the exercise training group compared with the control group.Conclusion: Incremental changes in NO-NO3-, NO2- axis are one of mechanisms through which HIIT program can protect the heart from I/R injury and decrease myocardial infarction.

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    APA: Copy

    FALLAHI, ALIASGHAR, GAEINI, ABBASALI, SHEKARFROUSH, SHAHNAZ, & KHOSHBATEN, ALI. (2015). CARDIOPROTECTIVE EFFECT OF HIGH INTENSITY INTERVAL TRAINING AND NITRIC OXIDE METABOLITES (NO2-, NO3-). IRANIAN JOURNAL OF PUBLIC HEALTH, 44(9), 1270-1276. SID. https://sid.ir/paper/273832/en

    Vancouver: Copy

    FALLAHI ALIASGHAR, GAEINI ABBASALI, SHEKARFROUSH SHAHNAZ, KHOSHBATEN ALI. CARDIOPROTECTIVE EFFECT OF HIGH INTENSITY INTERVAL TRAINING AND NITRIC OXIDE METABOLITES (NO2-, NO3-). IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2015;44(9):1270-1276. Available from: https://sid.ir/paper/273832/en

    IEEE: Copy

    ALIASGHAR FALLAHI, ABBASALI GAEINI, SHAHNAZ SHEKARFROUSH, and ALI KHOSHBATEN, “CARDIOPROTECTIVE EFFECT OF HIGH INTENSITY INTERVAL TRAINING AND NITRIC OXIDE METABOLITES (NO2-, NO3-),” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 44, no. 9, pp. 1270–1276, 2015, [Online]. Available: https://sid.ir/paper/273832/en

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