SERUM 25-HYDROXYVITAMIN D IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER

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DANA ALAMDARI LEILA; KHEIROURI SORAYYA; Noorazar Seyed Gholamreza

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Journal: Iranian Journal of Public Health Year:2015 | Volume:44 | Issue:5 Page(s): 690-697

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Information Journal Paper

Title

SERUM 25-HYDROXYVITAMIN D IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER

Author(s)

DANA ALAMDARI LEILA | KHEIROURI SORAYYA | Noorazar Seyed Gholamreza | Issue Writer Certificate

Keywords

VITAMIN D

DEPRESSION

DEPRESSION SEVERITY

CURRENT DEPRESSION

Abstract

Background: We investigated the association between serum 25 (OH) D levels and depressive symptoms in patients with major depressive disorder (MDD).Methods: Eighty-five adults, 44 drug free patients with MDD and 41 apparently healthy controls, participated in the study. The Hamilton DEPRESSION Rating Scale was used to assess severity of major DEPRESSION. Mental health of the controls was assessed according to DSM-IV criteria. Stress level of the participants was assessed by the Holmes and Rahe stress scale. Serum 25 (OH) D levels was measured by immunochemiluminescence assay. VITAMIN D deficiency was defined as a serum 25 (OH) D concentration of lower than 20 ng/ml.Results: Depressed patients had the higher levels of stress. There was a positive correlation between stress level and disease severity (r=0.32, P=0.03). In total participants, mean percentage of VITAMIN D deficiency was 77.6% with 75% in patients and 80.5% in the healthy subjects. There were no differences between the two groups in serum 25 (OH) D levels and percentage of subjects with the VITAMIN Deficiency. A negative correlation was observed between disease severity and serum 25 (OH) D level of patients with DEPRESSION episodes<2 y (r=-0.38, P=0.08) and winter samples (samples collected and measured from December to march, r=-0.62, P=0.004).Conclusion: Serum 25 (OH) D levels were not associated with DEPRESSION. However, the inverse relationship between levels of VITAMIN D and depressive symptoms in current DEPRESSION episodes and in sun-deprived season warrants further investigation.

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APA: Copy

DANA ALAMDARI, LEILA, KHEIROURI, SORAYYA, & Noorazar, Seyed Gholamreza. (2015). SERUM 25-HYDROXYVITAMIN D IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER. IRANIAN JOURNAL OF PUBLIC HEALTH, 44(5), 690-697. SID. https://sid.ir/paper/273921/en

Vancouver: Copy

DANA ALAMDARI LEILA, KHEIROURI SORAYYA, Noorazar Seyed Gholamreza. SERUM 25-HYDROXYVITAMIN D IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2015;44(5):690-697. Available from: https://sid.ir/paper/273921/en

IEEE: Copy

LEILA DANA ALAMDARI, SORAYYA KHEIROURI, and Seyed Gholamreza Noorazar, “SERUM 25-HYDROXYVITAMIN D IN PATIENTS WITH MAJOR DEPRESSIVE DISORDER,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 44, no. 5, pp. 690–697, 2015, [Online]. Available: https://sid.ir/paper/273921/en

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