مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

392
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

249
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

TESTICULAR FEMINIZATION OR ANDROGEN INSENSITIVITY SYNDROME (AIS) IN IRAN: A RETROSPECTIVE ANALYSIS OF 30-YEAR DATA

Pages

  1-5

Keywords

ANDROGEN INSENSITIVITY SYNDROME (AIS) 
HUMAN ANDROGEN RECEPTOR (HAR) 

Abstract

 Background: Androgen insensitivity syndrome (AIS) or TESTICULAR FEMINIZATION is a partial or complete inability of cell response to androgen. The cause is enzymatic defect in synthesis of testosterone, resulting sexually immature pheno-typically female, with primary AMENORRHEA. There are three categories of AIS, complete, partial and mild, depending on the degree of external genital masculinization. The aim of this study was to find out chromosomal abnormalities, and correlation between AIS and maternal/paternal age, parents' consanguineous marriage, family history and clinical ob-servation, in IRANian AIS patients.Method: This study includes a retrospective data analysis of 72, 000 families' medical records in the Genetic Clinic in Tehran, during a 30-yr period (1984-2014). The essential basis for the patients' referral to the clinic by gynecologists was primary AMENORRHEA. Cytogenetic abnormalities has been confirmed by chromosome G-banding and conventional staining methods.Results: Seventy AIS female patients with 46XY pattern were cytogenetically diagnosed and the frequency of AIS syndrome was estimated about 0.05% ( ~70.140000). The results showed no association between AIS and maternal or paternal age nor were the marital pattern of the parents. The clinical findings illustrated that primary AMENORRHEA had the highest indication for referral of AIS patients for genetic counseling and cytogenetic study.Conclusion: No correlation was observed between AIS and maternal or paternal age or consanguineous marriages. AMENORRHEA is the most clinically observed sign of AIS patients.

Cites

  • No record.

    • References

    Cite

    APA: Copy

    FARHUD, DARIUSH D., ZARIF YEGANEH, MARJAN, SADIGHI, HOSEIN, & ZANDVAKILI, SHAHRAM. (2016). TESTICULAR FEMINIZATION OR ANDROGEN INSENSITIVITY SYNDROME (AIS) IN IRAN: A RETROSPECTIVE ANALYSIS OF 30-YEAR DATA. IRANIAN JOURNAL OF PUBLIC HEALTH, 45(1), 1-5. SID. https://sid.ir/paper/273970/en

    Vancouver: Copy

    FARHUD DARIUSH D., ZARIF YEGANEH MARJAN, SADIGHI HOSEIN, ZANDVAKILI SHAHRAM. TESTICULAR FEMINIZATION OR ANDROGEN INSENSITIVITY SYNDROME (AIS) IN IRAN: A RETROSPECTIVE ANALYSIS OF 30-YEAR DATA. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2016;45(1):1-5. Available from: https://sid.ir/paper/273970/en

    IEEE: Copy

    DARIUSH D. FARHUD, MARJAN ZARIF YEGANEH, HOSEIN SADIGHI, and SHAHRAM ZANDVAKILI, “TESTICULAR FEMINIZATION OR ANDROGEN INSENSITIVITY SYNDROME (AIS) IN IRAN: A RETROSPECTIVE ANALYSIS OF 30-YEAR DATA,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 45, no. 1, pp. 1–5, 2016, [Online]. Available: https://sid.ir/paper/273970/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button