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Information Journal Paper

Title

ANTIFUNGAL SUSCEPTIBILITY ANALYSIS OF CLINICAL ISOLATES OF CANDIDA PARAPSILOSIS IN IRAN

Pages

  322-328

Abstract

 Background: CANDIDA PARAPSILOSIS is an emergent agent of invasive fungal infections. This yeast is one of the five most widespread yeasts concerned in invasive candidiasis.C. parapsilosis stands out as the second most common yeast species isolated from patients with bloodstream infections especially in neonates with catheter.Recently several reports suggested that its reduced susceptibility to azoles and polyene might become a cause for clini-cal concern, although C. parapsilosis is not believed to be intensely prone to the development of antifungal resistance.Methods: In the present report, One hundred and twenty clinical isolates of C. parapsilosis complex were identified and differentiated by using PCR-RFLP analysis. The isolates were then analyzed to determine their susceptibility pro-file to fluconazole (FLU), itraconazole (ITC) and amphotericin B. The minimum inhibitory concentration (MIC) re-sults were analyzed according to the standard CLSI guide.Results: All of isolates were identified as C. parapsilosis. No C. metapsilosis and C. orthopsilosis strains were found. Evalua-tion of the ANTIFUNGAL SUSCEPTIBILITY profile showed that only three (2.5%) C. parapsilosis were RESISTANT to fluconazole, three (2.5%) C. parapsilosis were RESISTANT to itraconazole and two (1.7%) C. parapsilosis were amphotericin B RESISTANT.Conclusion: Profiles in clinical isolates of C. parapsilosis can provide important information for the control of antifun-gal resistance as well as distribution and susceptibility profiles in populations.

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    Cite

    APA: Copy

    LOTFALI, ENSIEH, KORDBACHEH, PARIVASH, MIRHENDI, HOSSEIN, ZAINI, FARIDEH, GHAJARI, ALI, MOHAMMADI, RASOUL, NOORBAKHSH, FATEMEH, MOAZENI, MARYAM, FALLAHI, ALIAKBAR, & REZAIE, SASSAN. (2016). ANTIFUNGAL SUSCEPTIBILITY ANALYSIS OF CLINICAL ISOLATES OF CANDIDA PARAPSILOSIS IN IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH, 45(3), 322-328. SID. https://sid.ir/paper/274019/en

    Vancouver: Copy

    LOTFALI ENSIEH, KORDBACHEH PARIVASH, MIRHENDI HOSSEIN, ZAINI FARIDEH, GHAJARI ALI, MOHAMMADI RASOUL, NOORBAKHSH FATEMEH, MOAZENI MARYAM, FALLAHI ALIAKBAR, REZAIE SASSAN. ANTIFUNGAL SUSCEPTIBILITY ANALYSIS OF CLINICAL ISOLATES OF CANDIDA PARAPSILOSIS IN IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2016;45(3):322-328. Available from: https://sid.ir/paper/274019/en

    IEEE: Copy

    ENSIEH LOTFALI, PARIVASH KORDBACHEH, HOSSEIN MIRHENDI, FARIDEH ZAINI, ALI GHAJARI, RASOUL MOHAMMADI, FATEMEH NOORBAKHSH, MARYAM MOAZENI, ALIAKBAR FALLAHI, and SASSAN REZAIE, “ANTIFUNGAL SUSCEPTIBILITY ANALYSIS OF CLINICAL ISOLATES OF CANDIDA PARAPSILOSIS IN IRAN,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 45, no. 3, pp. 322–328, 2016, [Online]. Available: https://sid.ir/paper/274019/en

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