COMPARATIVE EVALUATION OF HEAVY METALS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY CONTROL IN PAKISTANI POPULATION

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IRFAN SHAZIA; RANI ASIMA; RIAZ NAILA; ARSHAD MUHAMMAD; NAWAZ SYED KASHIF

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Journal: Iranian Journal of Public Health Year:2017 | Volume:46 | Issue:5 Page(s): 626-633

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Title

COMPARATIVE EVALUATION OF HEAVY METALS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY CONTROL IN PAKISTANI POPULATION

Author(s)

Keywords

RHEUMATOID ARTHRITIS

HEAVY METALS

SERUM

PAKISTAN

Abstract

Background: Exposure to HEAVY METALS in development of many diseases has been investigated previously, specially created by oxidative stress. The etiology of RHEUMATOID ARTHRITIS (RA) is still not fully understood but oxidative stress created by HEAVY METALS may have role in development of RA. The aim of present study was to compare SERUM level of HEAVY METALS in RA and healthy control individuals.Methods: Blood samples of 100 RA patients were collected from different hospitals in district Sargodha, Punjab, Pa-kistan and 100 control individuals from Dec 2013 to May 2014. The SERUM samples were analyzed for determination of Pb, Cd, Cr and Ni through Atomic absorption spectrophotometer (AA 6600 Shimadzu).Results: Statistically highly significant difference was observed between RA patients and healthy control individuals for Pb, Cd, Cr, and Ni level (P<0.01). The difference between the means of both sexes was not significant for Pb and Cd concentrations (P>0.01). For Cr the difference between the means of both sexes was statistically not significant in RA+ve patients and highly significant difference was observed between both sexes in healthy control group (P<0.01). The difference between the means of both sexes for Ni was statistically non-significant in healthy control group while significant difference was observed between both sexes in RA+ve group (P<0.05). Statistically non-significant differ-ence for Pb, Cd, Cr and Ni level was found among the all three age groups of RA and healthy control individuals (P>0.01).Conclusion: Concentration of HEAVY METALS in SERUM samples of RA patients and healthy control individuals differ significantly, which shows that HEAVY METALS may contributes towards development of RA.

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APA: Copy

IRFAN, SHAZIA, RANI, ASIMA, RIAZ, NAILA, ARSHAD, MUHAMMAD, & NAWAZ, SYED KASHIF. (2017). COMPARATIVE EVALUATION OF HEAVY METALS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY CONTROL IN PAKISTANI POPULATION. IRANIAN JOURNAL OF PUBLIC HEALTH, 46(5), 626-633. SID. https://sid.ir/paper/274144/en

Vancouver: Copy

IRFAN SHAZIA, RANI ASIMA, RIAZ NAILA, ARSHAD MUHAMMAD, NAWAZ SYED KASHIF. COMPARATIVE EVALUATION OF HEAVY METALS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY CONTROL IN PAKISTANI POPULATION. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2017;46(5):626-633. Available from: https://sid.ir/paper/274144/en

IEEE: Copy

SHAZIA IRFAN, ASIMA RANI, NAILA RIAZ, MUHAMMAD ARSHAD, and SYED KASHIF NAWAZ, “COMPARATIVE EVALUATION OF HEAVY METALS IN PATIENTS WITH RHEUMATOID ARTHRITIS AND HEALTHY CONTROL IN PAKISTANI POPULATION,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 46, no. 5, pp. 626–633, 2017, [Online]. Available: https://sid.ir/paper/274144/en

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