THE ROLE OF INTRAHIPPOCAMPAL MICROINJECTIONS OF ANISOMYCIN ON DEXAMETHASONE-INDUCED MODULATION OF MEMORY CONSOLIDATION IN RATS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

VAFAEI ABAS ALI; YAZDANI A.; RASHIDIPOUR A.

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM) Year:2008 | Volume:10 | Issue:3 (SN 39) Page(s): 257-264

Download Full-Text

Persian Verion

View:

828

Download:

Cites:

Information Journal Paper

Title

THE ROLE OF INTRAHIPPOCAMPAL MICROINJECTIONS OF ANISOMYCIN ON DEXAMETHASONE-INDUCED MODULATION OF MEMORY CONSOLIDATION IN RATS

Author(s)

VAFAEI ABAS ALI | YAZDANI A. | RASHIDIPOUR A. | Issue Writer Certificate

Keywords

HIPPOCAMPUSQ2

PASSIVE AVOIDANCE LEARNINGQ3

MEMORY CONSOLIDATIONQ2

DEXAMETHASONEQ3

ANISOMYCINQ2

RATQ2

Abstract

Introduction: Evidence indicates that hipppocampus and activation of glucocorticoid receptors in this area are necessary for emotional learning and memory processes; also some studies suggest that glucocorticoid’s effects probably involve with processes of protein synthysis in the hippocmapus. The aim of this study was to determine the role of intrahippocampal microinjections of ANISOMYCIN [(ANS) as a protein synthysis inhibitor)] on DEXAMETHASONE-induced modulation of MEMORY CONSOLIDATION in the PASSIVE AVOIDANCE LEARNING (PAL) task in RATs. Material and Methods: In this study, 90 male Wistar RATs (250–300 gr) were surgically implanted bilaterally with cannulae aimed at the dorsal HIPPOCAMPUS (DH) were trained in PAL task. In experiment 1. DEXAMETHASONE (0.1, 0.5, 1 and 3 mg/kg IP) was injected immediately after training and vehicle injected into DH. In experiment 2. ANISOMYCIN (0.5, 1: g/:l/side) or vehicle were injected bilaterally into the DH followed immediately by IP injection of DEXAMETHASONE (1 mg/kg) or vehicle. Two days after training, retention tests were done and step-through latency (STL) and total time spent in light chamber (TLC) of apparatus were recorded during 10 min and compared with controls. Results: Data indicated that injection of DEXAMETHASONE immediatly after training enhanced MEMORY CONSOLIDATION (P<0.01) and this effect was blocked by injection of ANS in to the DH (P<0.01). Conclusion: The findings above showed that glucocorticoids play on important role in consolidation of emotional learning and probably in processes of protein synthesis in the HIPPOCAMPUS may play an important role in mediating these effects.

Cites

No record.

References

No record.

Cite

APA: Copy

VAFAEI, ABAS ALI, YAZDANI, A., & RASHIDIPOUR, A.. (2008). THE ROLE OF INTRAHIPPOCAMPAL MICROINJECTIONS OF ANISOMYCIN ON DEXAMETHASONE-INDUCED MODULATION OF MEMORY CONSOLIDATION IN RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 10(3 (SN 39)), 257-264. SID. https://sid.ir/paper/27418/en

Vancouver: Copy

VAFAEI ABAS ALI, YAZDANI A., RASHIDIPOUR A.. THE ROLE OF INTRAHIPPOCAMPAL MICROINJECTIONS OF ANISOMYCIN ON DEXAMETHASONE-INDUCED MODULATION OF MEMORY CONSOLIDATION IN RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2008;10(3 (SN 39)):257-264. Available from: https://sid.ir/paper/27418/en

IEEE: Copy

ABAS ALI VAFAEI, A. YAZDANI, and A. RASHIDIPOUR, “THE ROLE OF INTRAHIPPOCAMPAL MICROINJECTIONS OF ANISOMYCIN ON DEXAMETHASONE-INDUCED MODULATION OF MEMORY CONSOLIDATION IN RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 10, no. 3 (SN 39), pp. 257–264, 2008, [Online]. Available: https://sid.ir/paper/27418/en

Related Journal Papers