مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

231
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

203
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

HEPATIC PROTEINS AND INFLAMMATORY MARKERS IN RHEUMATOID ARTHRITIS PATIENTS

Pages

  1071-1078

Abstract

 Background: RHEUMATOID ARTHRITIS is an autoimmune inflammatory rheumatic disease that causes chronic synovialinflammation eventually leading to joint destruction and disability. The aim of this study was to determine the variationsof HEPATIC PROTEINS, myeloperoxidase, and iron in RHEUMATOID ARTHRITIS Tunisian patients and their implications ininflammation and in IRON METABOLISM.Methods: Overall, 172 patients from the Rheumatology Department of the University Hospital “Farhat Hached”, Sousse-Tunisia between 2011 and 2012, with RHEUMATOID ARTHRITIS (97.1% women, average age: 48±13 yr) and 147healthy volunteers (70.1% women, average age: 46 ± 7 yr) were included in this study. Serum HEPATIC PROTEINS (highsensitiveC-reactive protein, ceruloplasmin, albumin, transferrin, α-1-acid glycoprotein and haptoglobin) were assessedby immunoturbidimetry (COBAS INTEGRA 400, Roche) and ferritin was measured by a microparticulateimmunoenzymatic technic (AxSYM, ABBOTT, Germany), Plasma myeloperoxidase was determined by Enzyme-Linked Immunosorbent Assay. Serum iron was measured according to a colorimetric method at 595 nm (CX9-BECKMANN Coulter-Fuller-Ton, CA).Results: Significantly higher levels of high-sensitive C-reactive protein, a-1-acid glycoprotein, Haptoglobin and myeloperoxidasein patients compared to controls (P<10-3). Albumin and iron rates were significantly decreased in patientscompared to healthy group (P=0.026 and P<10-3, respectively). There were no differences between cases andcontrols for levels of ceruloplasmin, transferrin and ferritin (P=0.782, P=0.808, and P=0.175, respectively).Conclusion: The high-sensitive C-reactive protein, α-1-acid glycoprotein, and haptoglobin increased in acute phaseproteins in RHEUMATOID ARTHRITIS disease. The pro-inflammatory cytokines affect IRON METABOLISM leading to the irondeficiency and rheumatoid anemia, which influenced Tf and ferritin levels.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    BEN HADJ MOHAMED, MANEL. (2017). HEPATIC PROTEINS AND INFLAMMATORY MARKERS IN RHEUMATOID ARTHRITIS PATIENTS. IRANIAN JOURNAL OF PUBLIC HEALTH, 46(8), 1071-1078. SID. https://sid.ir/paper/274225/en

    Vancouver: Copy

    BEN HADJ MOHAMED MANEL. HEPATIC PROTEINS AND INFLAMMATORY MARKERS IN RHEUMATOID ARTHRITIS PATIENTS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2017;46(8):1071-1078. Available from: https://sid.ir/paper/274225/en

    IEEE: Copy

    MANEL BEN HADJ MOHAMED, “HEPATIC PROTEINS AND INFLAMMATORY MARKERS IN RHEUMATOID ARTHRITIS PATIENTS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 46, no. 8, pp. 1071–1078, 2017, [Online]. Available: https://sid.ir/paper/274225/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button