INSERTION/DELETION POLYMORPHISMS AND SERUM ANGIOTENSIN-CONVERTING ENZYME LEVELS IN IRANIAN PATIENTS WITH SARCOIDOSIS

Q: How can I download an article?

To download an article from SID, first log in to the site, search for the article title, and click on the 'Download Article' option.

Q: How can I download an ISI article?

To download an ISI article on SID, enter the keyword or article title in the search bar, view the relevant results, click on the desired article, and select the 'Download Article' option.

Q: How can I access the SID database?

To access the SID database, visit SID.ir, create an account, and log in to access scientific resources.

Q: Is downloading articles from SID free?

Some articles on SID are available for free, while others require payment. Details are specified on the article's page.

JAVADI ALIREZA

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: Iranian Journal of Public Health Year:2016 | Volume:45 | Issue:11 Page(s): 1473-1480

Download Full-Text

View:

271

Download:

169

Cites:

Information Journal Paper

Title

INSERTION/DELETION POLYMORPHISMS AND SERUM ANGIOTENSIN-CONVERTING ENZYME LEVELS IN IRANIAN PATIENTS WITH SARCOIDOSIS

Author(s)

JAVADI ALIREZA | Issue Writer Certificate

Keywords

SARCOIDOSIS

ACE GENE POLYMORPHISM

ANGIOTENSIN CONVERTING ENZYME

Abstract

Background: SARCOIDOSIS is a multisystem inflammatory disease of unknown origin with characterization of small granulomas. Angiotensin-converting enzyme (ACE) is a pathophysiologic marker of SARCOIDOSIS. We present the ACE insertion/deletion (I/D) polymorphism in correlation with serum ACE level in Iranian patients with SARCOIDOSIS.Methods: From Jan 2014 to Jan 2015, 102 Iranian patients who histopathologically diagnosed for SARCOIDOSIS and 192 healthy age and sex-matched controls were recruited. PCR was used for detection of I/D polymorphism in ACE gene.Results: Frequency of II/ID/DD genotype in SARCOIDOSIS disease was 17%, 35.5%, and 47.1%, respectively. The frequency of D allele was 0.65. A significant association between I/D genotypes and mean of sACE level was seen (DD=85.2±22.9, P<0.001). More frequent genotype in SARCOIDOSIS patients was DD (47%), ID genotype (45.9%) was found more in controls. Logistic regression analysis adjusting age and sex showed that ID to II (OR=0.35, 95%CI=0.17-0.73, P=0.005) and DD to II (OR=2.11, 95%CI=0.98-4.54, P=0.05) could be considered as a predictor factor for the disease activity. No significant model for men in SARCOIDOSIS group was seen, while women with II/ID were associated with a reduced risk for the disease.Conclusion: Although more regional studies with appropriate statistical scale must be done to provide a better diag-nosis and prognostic tool for this disease, this study demonstrates that ID and DD genotype could be predictive fac-tors for SARCOIDOSIS.

Multimedia

No record.

Cites

No record.

References

No record.

Cite

APA: Copy

JAVADI, ALIREZA. (2016). INSERTION/DELETION POLYMORPHISMS AND SERUM ANGIOTENSIN-CONVERTING ENZYME LEVELS IN IRANIAN PATIENTS WITH SARCOIDOSIS. IRANIAN JOURNAL OF PUBLIC HEALTH, 45(11), 1473-1480. SID. https://sid.ir/paper/274418/en

Vancouver: Copy

JAVADI ALIREZA. INSERTION/DELETION POLYMORPHISMS AND SERUM ANGIOTENSIN-CONVERTING ENZYME LEVELS IN IRANIAN PATIENTS WITH SARCOIDOSIS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2016;45(11):1473-1480. Available from: https://sid.ir/paper/274418/en

IEEE: Copy

ALIREZA JAVADI, “INSERTION/DELETION POLYMORPHISMS AND SERUM ANGIOTENSIN-CONVERTING ENZYME LEVELS IN IRANIAN PATIENTS WITH SARCOIDOSIS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 45, no. 11, pp. 1473–1480, 2016, [Online]. Available: https://sid.ir/paper/274418/en

Related Journal Papers

No record.

Related Seminar Papers

No record.

Related Plans

No record.

Recommended Workshops