ASSOCIATION OF COX-2 PROMOTER POLYMORPHISMS -765G/C AND -1195A/G WITH MIGRAINE

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MOZAFFARI ELAHE; DOOSTI ABBAS; ARSHI ASGHAR; FAGHANI MOSTAFA

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Journal Paper

Paper Information

Journal: Iranian Journal of Public Health Year:2016 | Volume:45 | Issue:12 Page(s): 1625-1635

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Title

ASSOCIATION OF COX-2 PROMOTER POLYMORPHISMS -765G/C AND -1195A/G WITH MIGRAINE

Author(s)

MOZAFFARI ELAHE | DOOSTI ABBAS | ARSHI ASGHAR | FAGHANI MOSTAFA | Issue Writer Certificate

Keywords

MIGRAINE

COX-2 GENE

POLYMORPHISM

RFLP

IRAN

Abstract

Background: MIGRAINE is a common debilitating primary headache disorder with current head pain attacks, which contributes to physical activity dysfunctions in chronic pain phase. PGE2 and PGI2 are two important prostaglandins synthesised by COX-2 enzymes, involved in MIGRAINE pain signals. COX-2 modulation is essential in treatment and pathogenesis of MIGRAINE. This study aimed to investigating the association between COX-2 GENE POLYMORPHISMs with the risk of MIGRAINE susceptibility in MIGRAINE patients with related and unrelated parents.Methods: This case- control study was based on 100 MIGRAINE patients and 100 non-MIGRAINE subjects in Bushehr province, IRAN in 2013. Genomic DNA of blood samples was extracted and genotyping of COX-2-765G>C (rs20417) and COX-2-1195A>G (rs689466) gene variants was investigated by PCR-RFLP method. Statistical analyses were ac-complished using the SPSS software package.Results: There was a significant differences in the frequencies of the COX-2-765G>C and COX-2-1195A>G genotypes between MIGRAINE patients and controls (P≤0.05).Conclusion: COX-2-765CC, COX-2-765CG, COX-2-1195GG and COX-2-1195AG genotypes can increase the risk of MIGRAINE significantly. As the first study in IRAN, we are hopeful to achieve greater results about the relevancy of COX-2 GENE, MIGRAINE and pain signals pathway by repeating these experiments on more samples

Cites

ANGIOGENESIS: A REVIEW OF MOLECULAR MECHANISM

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APA: Copy

MOZAFFARI, ELAHE, DOOSTI, ABBAS, ARSHI, ASGHAR, & FAGHANI, MOSTAFA. (2016). ASSOCIATION OF COX-2 PROMOTER POLYMORPHISMS -765G/C AND -1195A/G WITH MIGRAINE. IRANIAN JOURNAL OF PUBLIC HEALTH, 45(12), 1625-1635. SID. https://sid.ir/paper/274450/en

Vancouver: Copy

MOZAFFARI ELAHE, DOOSTI ABBAS, ARSHI ASGHAR, FAGHANI MOSTAFA. ASSOCIATION OF COX-2 PROMOTER POLYMORPHISMS -765G/C AND -1195A/G WITH MIGRAINE. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2016;45(12):1625-1635. Available from: https://sid.ir/paper/274450/en

IEEE: Copy

ELAHE MOZAFFARI, ABBAS DOOSTI, ASGHAR ARSHI, and MOSTAFA FAGHANI, “ASSOCIATION OF COX-2 PROMOTER POLYMORPHISMS -765G/C AND -1195A/G WITH MIGRAINE,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 45, no. 12, pp. 1625–1635, 2016, [Online]. Available: https://sid.ir/paper/274450/en

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