LONG CHAIN N-3 FATTY ACIDS IMPROVE DEPRESSION SYNDROME IN TYPE 2 DIABETES MELLITUS

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MAZAHERIOUN MARYAM

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

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Journal: Iranian Journal of Public Health Year:2018 | Volume:47 | Issue:4 Page(s): 575-583

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Title

LONG CHAIN N-3 FATTY ACIDS IMPROVE DEPRESSION SYNDROME IN TYPE 2 DIABETES MELLITUS

Author(s)

MAZAHERIOUN MARYAM | Issue Writer Certificate

Keywords

DEPRESSION

N-3 FATTY ACIDS

TYPE 2 DIABETES MELLITUS

RANDOMIZED CONTROLLED TRIAL

Abstract

Background: TYPE 2 DIABETES MELLITUS (T2DM) is commonly associated with depressive symptoms, which af-fect prognosis and quality of life. We investigated the antidepressant effects of N-3 FATTY ACIDS (n-3FAs) mono-therapy (without conventional antidepressants) for T2DM patients with mild to moderate depressive symp-toms. Methods: A 10-wk, placebo-controlled, double-blind, parallel-group (1: 1 ratio) randomized trial of n-3FAs (2700 mg/day EPA: DHA ratio=2) versus placebo in 88 Iranian diabetic patients with mild to moderate de-pression based on Beck DEPRESSION Inventory II (BDI-II-PERSIAN) was conducted. This study started from July 2014 to January 2015 in Tehran University of Medical Sciences, Tehran, Iran. The primary event was de-fined as worsened, non-changed, or inconsiderably improved DEPRESSION (<5 unit decrease in BDI-II-PERSIAN DEPRESSION scores after treatment) (ClinicalTrials. gov Identifier: NCT02261545). Results: Randomly, 44 T2DM patients were treated with n-3FAs supplements and 44 cases received placebo (three patients discontinued). n-3FAs could significantly protect patients against the aforesaid event and exhibit satisfactory prevention (number needed to treat with 95% confidence interval: 2. 52, 1. 71-4. 74). No serious ad-verse reactions were reported. Conclusion: n-3FAs supplementation had significant antidepressant effects in T2DM patients with mild to moderate depressive symptoms, not confounded by metabolic factors and disease duration.

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APA: Copy

MAZAHERIOUN, MARYAM. (2018). LONG CHAIN N-3 FATTY ACIDS IMPROVE DEPRESSION SYNDROME IN TYPE 2 DIABETES MELLITUS. IRANIAN JOURNAL OF PUBLIC HEALTH, 47(4), 575-583. SID. https://sid.ir/paper/274532/en

Vancouver: Copy

MAZAHERIOUN MARYAM. LONG CHAIN N-3 FATTY ACIDS IMPROVE DEPRESSION SYNDROME IN TYPE 2 DIABETES MELLITUS. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2018;47(4):575-583. Available from: https://sid.ir/paper/274532/en

IEEE: Copy

MARYAM MAZAHERIOUN, “LONG CHAIN N-3 FATTY ACIDS IMPROVE DEPRESSION SYNDROME IN TYPE 2 DIABETES MELLITUS,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 47, no. 4, pp. 575–583, 2018, [Online]. Available: https://sid.ir/paper/274532/en

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