ANTHROPOMETRIC INDICES AS PREDICTORS OF CORONARY HEART DISEASE RISK: JOINT MODELING OF LONGITUDINAL MEASUREMENTS AND TIME TO EVENT

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GILANI NEDA; KAZEMNEJAD ANOSHIRVAN; ZAYERI FARID; HADAEGH FARZAD; AZIZI FEREIDOUN; KHALILI DAVOUD

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Journal: Iranian Journal of Public Health Year:2017 | Volume:46 | Issue:11 Page(s): 1546-1554

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Title

ANTHROPOMETRIC INDICES AS PREDICTORS OF CORONARY HEART DISEASE RISK: JOINT MODELING OF LONGITUDINAL MEASUREMENTS AND TIME TO EVENT

Author(s)

Keywords

CORONARY HEART DISEASE

BODY MASS INDEX

WAIST CIRCUMFERENCE

WAIST HIP RATIO

HEIGHT

JOINT MODEL

Abstract

Background: The prevalence of overweight and obesity have increased dramatically worldwide and together they constitute a major risk factor for CORONARY HEART DISEASE (CHD). The aim of this study was to assess the repeated mea-surements of BODY MASS INDEX (BMI), WAIST CIRCUMFERENCE (WC), waist to hip ratio (WHR) and waist to HEIGHT ratio (WHtR) in predicting CHD incidence. Methods: This longitudinal study was conducted within the framework of the Tehran Lipid and Glucose Study be-tween 1999– 2011, on 1959 women and 1371 men participants’ ages ≥ 30 yr, without a history of CVD. A JOINT MODEL-ing approach was utilized for data analysis using R software. The resulting JOINT MODEL allowed measuring α (quantifies the association between anthropometric indices up to time t and the hazard for CHD event at the same time point). Results: About 9% of the participants (7. 1% of the women and 11. 7% of the men) experienced CHD event during follow-up. The results indicated a significant linear increasing trend in BMI, WC, WHR, and WHtR over time (P<0. 001). The increased risk of CHD event in females increases with the values of BMI (α = 0. 004, P=0. 023), WC (α = 0. 018, P=0. 009), WHR (α = 0. 067, P=0. 014) and WHtR (α = 0. 106, P=0. 002). Furthermore, in males the risk of CHD risk increases by the values of BMI (α = 0. 005, P=0. 032), WC (α = 0. 019, P=0. 008), WHR (α = 0. 043, P=0. 015) and WHtR (α = 0. 096, P=0. 002). Conclusion: By jointly modeling longitudinal data with time-to-event outcomes, our study revealed that WHtR is su-perior to other indices in predicting CHD incidence.

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APA: Copy

GILANI, NEDA, KAZEMNEJAD, ANOSHIRVAN, ZAYERI, FARID, HADAEGH, FARZAD, AZIZI, FEREIDOUN, & KHALILI, DAVOUD. (2017). ANTHROPOMETRIC INDICES AS PREDICTORS OF CORONARY HEART DISEASE RISK: JOINT MODELING OF LONGITUDINAL MEASUREMENTS AND TIME TO EVENT. IRANIAN JOURNAL OF PUBLIC HEALTH, 46(11), 1546-1554. SID. https://sid.ir/paper/274680/en

Vancouver: Copy

GILANI NEDA, KAZEMNEJAD ANOSHIRVAN, ZAYERI FARID, HADAEGH FARZAD, AZIZI FEREIDOUN, KHALILI DAVOUD. ANTHROPOMETRIC INDICES AS PREDICTORS OF CORONARY HEART DISEASE RISK: JOINT MODELING OF LONGITUDINAL MEASUREMENTS AND TIME TO EVENT. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2017;46(11):1546-1554. Available from: https://sid.ir/paper/274680/en

IEEE: Copy

NEDA GILANI, ANOSHIRVAN KAZEMNEJAD, FARID ZAYERI, FARZAD HADAEGH, FEREIDOUN AZIZI, and DAVOUD KHALILI, “ANTHROPOMETRIC INDICES AS PREDICTORS OF CORONARY HEART DISEASE RISK: JOINT MODELING OF LONGITUDINAL MEASUREMENTS AND TIME TO EVENT,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 46, no. 11, pp. 1546–1554, 2017, [Online]. Available: https://sid.ir/paper/274680/en

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