مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

video

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

sound

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Persian Version

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

View:

197
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Download:

170
مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Cites:

Information Journal Paper

Title

ISOLATION AND CHARACTERIZATION OF CLINICAL TRIAZOLE RESISTANCE ASPERGILLUS FUMIGATUS IN IRAN

Pages

  994-1000

Abstract

 Background: ASPERGILLUS FUMIGATUS is a major cause of allergic syndromes, aspergilloma and life-threatening inva-sive infections in immunocompromised hosts. To date, a wide range of mutations in A. fumigatushave been de-scribed conferring azole-resistance, which commonly involves modifications in the cyp51A-gene (substitutions at codons G54, G138, P216, F219, M220, G448 and specifically codon L98 in combination with a 34-bp tan-dem repeat in the promoter region of the gene), the target for azole antifungals. We investigated the prevalence of azole-resistance in clinical A. fumigatus isolates obtained from patients in IRAN during 2010 to 2014. Methods: Overall, 172clinical A. fumigatus isolates obtained from patients with underlying disease including transplantation, granulocytopenia, chronic liver disease, chronic obstructive pulmonary disease (COPD) and allergic bronchopulmonary aspergillosis (ABPA). Samples were collected between Jan 2009 and Nov 2014 from five provinces of IRAN (Tehran, Shiraz, Isfahan, Khorasan razavi and East Azerbaijan). Antifungal susceptibility test was determined according to EUCAST reference method for itraconazole (ITC), voriconazole (VRC) and posaconazole (POS). All isolates were confirmed by amplification of the partial tubulin gene. Results: Of 172 A. fumigatus isolates tested, six isolates (3. 5%) had high MIC values of ITC (>16 mg/L) and VRC (≥ 4 mg/L). All six isolates showed a multi-resistant phenotype with high MICs of ITC and VRC. Conclusion: We determined in-vitro susceptibility a profile of 172 clinically isolates of A. fumigatus against tria-zole in IRAN. Azole-resistance is an emerging problem in A. fumigatus and international surveillance is warranted.

Cites

  • No record.

    • References

  • No record.

    • Cite

    APA: Copy

    MOHAMMADI, FAEZEZEH, HASHEMI, SEYED JAMAL, SEYEDMOUSAVI, SEYEDMOJTABA, & AKBARZADE, DORNA. (2018). ISOLATION AND CHARACTERIZATION OF CLINICAL TRIAZOLE RESISTANCE ASPERGILLUS FUMIGATUS IN IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH, 47(7), 994-1000. SID. https://sid.ir/paper/274825/en

    Vancouver: Copy

    MOHAMMADI FAEZEZEH, HASHEMI SEYED JAMAL, SEYEDMOUSAVI SEYEDMOJTABA, AKBARZADE DORNA. ISOLATION AND CHARACTERIZATION OF CLINICAL TRIAZOLE RESISTANCE ASPERGILLUS FUMIGATUS IN IRAN. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2018;47(7):994-1000. Available from: https://sid.ir/paper/274825/en

    IEEE: Copy

    FAEZEZEH MOHAMMADI, SEYED JAMAL HASHEMI, SEYEDMOJTABA SEYEDMOUSAVI, and DORNA AKBARZADE, “ISOLATION AND CHARACTERIZATION OF CLINICAL TRIAZOLE RESISTANCE ASPERGILLUS FUMIGATUS IN IRAN,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 47, no. 7, pp. 994–1000, 2018, [Online]. Available: https://sid.ir/paper/274825/en

    Related Journal Papers

  • No record.

    • Related Seminar Papers

  • No record.

    • Related Plans

  • No record.

    • Recommended Workshops






    Move to top
    telegram sharing button
    whatsapp sharing button
    linkedin sharing button
    twitter sharing button
    email sharing button
    email sharing button
    email sharing button
    sharethis sharing button