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Information Journal Paper

Title

Target Site Insensitivity Detection in Deltamethrin Resistant Culex pipiens Complex in Iran

Pages

  1091-1098

Abstract

 Background: Some mosquito species which belong to the Culex. pipiens complex are primary vectors for West Nile virus, Sindbis, Dirofilaria immitis, and many arboviruses. Knockdown resistance (kdr) mutations in the volt-age-gated sodium channel (VGSC) gene of Cx. pipiens that is inherited, is one of the important threats for the efficacy of pyrethroids insecticides. Knockdown resistance (kdr) mutation, L1014F, is a well-defined mecha-nism of resistance to pyrethroids and DDT in many insect species. The aim of study was to determine the mechanisms of Insecticide resistance in this species Methods: Specimens of Cx. pipiens, the major vector of West Nile virus, were obtained in Tehran, Iran by col-lecting larvae from polluted wastewater in Qarchak of Tehran. In 2016 Insecticide susceptibility tests were per-formed according to WHO methods with Deltamethrin 0. 05%. We focused on determination of this point mu-tation in the VGSC gene of Cx. pipiens by Real-time PCR. Results: Our results revealed high levels of resistance to Deltamethrin 0. 05%. The lethal times i. e. LT50 and LT90 for Deltamethrin were 2. 1530 and 8. 5117 h respectively. The result of Real-time PCR confirmed the pres-ence of resistant genotype in all the members of tested population. This study is the first report on kdr geno-typing of Cx. pipiens from Tehran and our results on the VGSC gene in position L1014F confirmed the TTA to TTT nucleotide change. Conclusion: This finding will provide a clue for management of insecticide resistance in mosquito which are vectors of arboviruses and decision for replacement of novel approach for vector control.

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    APA: Copy

    ZEIDABADINEZHAD, Reza, VATANDOOST, HASSAN, ABAI, MOHAMMAD REZA, DINPARAST DJADID, NAVID, RAZ, ABBASALI, SEDAGHAT, MOHAMMAD MAHDI, OSHAGHI, Mohamad Ali, RAEISI, AHMAD, & ADIBI, NEDA. (2019). Target Site Insensitivity Detection in Deltamethrin Resistant Culex pipiens Complex in Iran. IRANIAN JOURNAL OF PUBLIC HEALTH, 48(6), 1091-1098. SID. https://sid.ir/paper/274941/en

    Vancouver: Copy

    ZEIDABADINEZHAD Reza, VATANDOOST HASSAN, ABAI MOHAMMAD REZA, DINPARAST DJADID NAVID, RAZ ABBASALI, SEDAGHAT MOHAMMAD MAHDI, OSHAGHI Mohamad Ali, RAEISI AHMAD, ADIBI NEDA. Target Site Insensitivity Detection in Deltamethrin Resistant Culex pipiens Complex in Iran. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2019;48(6):1091-1098. Available from: https://sid.ir/paper/274941/en

    IEEE: Copy

    Reza ZEIDABADINEZHAD, HASSAN VATANDOOST, MOHAMMAD REZA ABAI, NAVID DINPARAST DJADID, ABBASALI RAZ, MOHAMMAD MAHDI SEDAGHAT, Mohamad Ali OSHAGHI, AHMAD RAEISI, and NEDA ADIBI, “Target Site Insensitivity Detection in Deltamethrin Resistant Culex pipiens Complex in Iran,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 48, no. 6, pp. 1091–1098, 2019, [Online]. Available: https://sid.ir/paper/274941/en

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