Comparing the Efficacy of Angiotensin Converting Enzyme In-hibitors with Calcium Channel Blockers on the Treatment of Di-abetic Nephropathy: A Meta-Analysis

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ZHANG Zhaowei; CHEN Chunlin; LV Shiwen; ZHU Yalan; FANG Tianzi

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Journal: Iranian Journal of Public Health Year:2019 | Volume:48 | Issue:2 Page(s): 189-197

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Title

Comparing the Efficacy of Angiotensin Converting Enzyme In-hibitors with Calcium Channel Blockers on the Treatment of Di-abetic Nephropathy: A Meta-Analysis

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Keywords

Diabetic nephropathy

Angiotensin converting enzyme inhibitors

Calcium channel blockers

Meta-analysis

Abstract

Background: The angiotensin-converting enzyme inhibitors (ACEIs) could improve the symptoms of Diabetic nephropathy. Whether the Calcium channel blockers (CCBs) could be as effective as ACEIs on treating Diabetic nephropathy is controversial. Here, we aimed to compare the efficacy of ACEIs with CCBs on the treatment of Diabetic nephropathy by performing a Meta-analysis of randomized controlled trials (RCTs). Methods: The Pubmed, Medline, Embase and The Cochrane Database were searched up to July 2017 for eli-gible randomized clinical trials studies. Effect sizes were summarized as mean difference (MD) or standardized mean difference (SMD) with 95% confidence intervals (P-value<0. 05). Results: Seven RCTs involving 430 participants comparing ACEIs with CCBs were included. No benefit was seen in comparative group of ACEIs on systolic blood pressure（ SBP） (MD=1. 05 mmHg; 95% CI:-0. 97 to 3. 08, P=0. 31), diastolic blood pressure (DBP) (MD=-0. 34 mmHg; 95% CI:-1. 2 to 0. 51, P=0. 43), urinary al-bumin excretion rates (UAER) (MD=1. 91μ g/min; 95% CI:-10. 3 to 14. 12, P=0. 76), 24-h urine protein (24-UP) (SMD=-0. 26; 95%CI:-0. 55 to 0. 03, P=0. 08), glomerular filtration rate (GFR) (SMD=0. 01; 95% CI:-0. 38 to 0. 41, P=0. 95). On safety aspect, the risk of adverse reactions between ACEIs group and CCBs group are simi-lar (RR=1. 18; 95% CI: 0. 61 to 2. 28; P=0. 61). Conclusion: Both ACEIs and CCBs could improve the BP, UAER, 24h-UP, and GFR of diabetic nephropa-thy to a similar extent.

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APA: Copy

ZHANG, Zhaowei, CHEN, Chunlin, LV, Shiwen, ZHU, Yalan, & FANG, Tianzi. (2019). Comparing the Efficacy of Angiotensin Converting Enzyme In-hibitors with Calcium Channel Blockers on the Treatment of Di-abetic Nephropathy: A Meta-Analysis. IRANIAN JOURNAL OF PUBLIC HEALTH, 48(2), 189-197. SID. https://sid.ir/paper/274980/en

Vancouver: Copy

ZHANG Zhaowei, CHEN Chunlin, LV Shiwen, ZHU Yalan, FANG Tianzi. Comparing the Efficacy of Angiotensin Converting Enzyme In-hibitors with Calcium Channel Blockers on the Treatment of Di-abetic Nephropathy: A Meta-Analysis. IRANIAN JOURNAL OF PUBLIC HEALTH[Internet]. 2019;48(2):189-197. Available from: https://sid.ir/paper/274980/en

IEEE: Copy

Zhaowei ZHANG, Chunlin CHEN, Shiwen LV, Yalan ZHU, and Tianzi FANG, “Comparing the Efficacy of Angiotensin Converting Enzyme In-hibitors with Calcium Channel Blockers on the Treatment of Di-abetic Nephropathy: A Meta-Analysis,” IRANIAN JOURNAL OF PUBLIC HEALTH, vol. 48, no. 2, pp. 189–197, 2019, [Online]. Available: https://sid.ir/paper/274980/en

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