ANTICONVULSANT ACTIVITIES OF NEW 1,4DIHYDROPYRIDINE DERIVATIVES CONTAINING 4-NITROIMIDAZOLYL SUBSTITUENTS

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RASTKARI N.; SHARIFZADEH MOHAMMAD

مرکز اطلاعات علمی Scientific Information Database (SID) - Trusted Source for Research and Academic Resources

Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2004 | Volume:12 | Issue:2 Page(s): 81-86

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Information Journal Paper

Title

ANTICONVULSANT ACTIVITIES OF NEW 1,4DIHYDROPYRIDINE DERIVATIVES CONTAINING 4-NITROIMIDAZOLYL SUBSTITUENTS

Author(s)

RASTKARI N. | SHARIFZADEH MOHAMMAD | Issue Writer Certificate

Keywords

CALCIUM CHANNEL BLOCKERS

NITROIMIDAZOLE

DIHYDROPYRIDINES

ANTICONVULSION

Abstract

Anticonvulsant activity of Alkyl, cycloalkyl and arylalkyl ester analogues of nifedipine in which the ortho-nitro phenyl group at position 4 is replaced by 1-methy l-4-nitro-5-imidazolyl substituent, were determined against pentylenetetrazole-induced seizures in mice. The anticonvulsant effects of the compounds were evaluated by the measurement of seizure latency and duration. Significant differences were observed between treated animals with control group and nifedipine in seizure duration. Our results show that most of the compounds had similar activity to the reference drug nifedipine. In addition, compounds 6a, 6b, 6f, 6g, 6h, 8e, 8f, 8g , 8h and 8i were more active than the reference drug nifedipine.

Cites

SYNTHESIS AND ANTICONVULSANT ACTIVITY OF NOVEL 2-AMINO-5-[4-CHLORO-2-(2-CHLOROPHENOXY) PHENYL]-1,3,4-THIADIAZOLE DERIVATIVES

References

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APA: Copy

RASTKARI, N., & SHARIFZADEH, MOHAMMAD. (2004). ANTICONVULSANT ACTIVITIES OF NEW 1,4DIHYDROPYRIDINE DERIVATIVES CONTAINING 4-NITROIMIDAZOLYL SUBSTITUENTS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 12(2), 81-86. SID. https://sid.ir/paper/275211/en

Vancouver: Copy

RASTKARI N., SHARIFZADEH MOHAMMAD. ANTICONVULSANT ACTIVITIES OF NEW 1,4DIHYDROPYRIDINE DERIVATIVES CONTAINING 4-NITROIMIDAZOLYL SUBSTITUENTS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2004;12(2):81-86. Available from: https://sid.ir/paper/275211/en

IEEE: Copy

N. RASTKARI, and MOHAMMAD SHARIFZADEH, “ANTICONVULSANT ACTIVITIES OF NEW 1,4DIHYDROPYRIDINE DERIVATIVES CONTAINING 4-NITROIMIDAZOLYL SUBSTITUENTS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 12, no. 2, pp. 81–86, 2004, [Online]. Available: https://sid.ir/paper/275211/en

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