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Information Journal Paper

Title

INFLUENCE OF FORMULATION VARIABLES AND INHALATION DEVICE ON THE DEPOSITION PROFILES OF CROMOLYN SODIUM DRY POWDER AEROSOLS

Author(s)

 GILANI K. | ROUH ALAMINI NAJAFABADI A.A.H. | DARABI M. | BARGHI M.A. | RAFIEI TEHRANI M. | Issue Writer Certificate 

Pages

  123-130

Abstract

 Dry powder inhalers (DPIs) have attained considerable attention due to their propellant-free formulations and the patient’s inherent coordination with actuation. Generally, DPI formulations consist of a micronized drug alone or mixed with carrier particles. This study was carried out to investigate the effects of carrier PARTICLE SIZE and weight fraction on aerosolisation behaviour of CROMOLYN SODIUM (CS). Pharmatose® 450M and Pharmatose® 325M, two commercial α-lactose monohydrate with different particle sizes, were blended in two different fractions (30 and 50% w/w) with CS. A low resistance device (Spinhaler®) and a medium resistance device (Cyclohaler®), were used to evaluate the effect of inhaler design on the deposition profiles of CS.The in vitro deposition of the formulations was determined using a twin stage impinger (TSI). Fine particle dose, fine particle fraction and emitted dose of the drug were depended to both formulation and inhalation devices. Fine particle fractions of the drug aerosolised from the formulations ranged from 9.35 up to 36.45%. The highest fine particle fraction was produced by formulation containing 50% Pharmatose® 450M as carrier. Cyclohaler® showed higher efficiency in aerosolisation of CS compared to Spinhaler®.

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    Cite

    APA: Copy

    GILANI, K., ROUH ALAMINI NAJAFABADI, A.A.H., DARABI, M., BARGHI, M.A., & RAFIEI TEHRANI, M.. (2004). INFLUENCE OF FORMULATION VARIABLES AND INHALATION DEVICE ON THE DEPOSITION PROFILES OF CROMOLYN SODIUM DRY POWDER AEROSOLS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 12(3), 123-130. SID. https://sid.ir/paper/275215/en

    Vancouver: Copy

    GILANI K., ROUH ALAMINI NAJAFABADI A.A.H., DARABI M., BARGHI M.A., RAFIEI TEHRANI M.. INFLUENCE OF FORMULATION VARIABLES AND INHALATION DEVICE ON THE DEPOSITION PROFILES OF CROMOLYN SODIUM DRY POWDER AEROSOLS. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2004;12(3):123-130. Available from: https://sid.ir/paper/275215/en

    IEEE: Copy

    K. GILANI, A.A.H. ROUH ALAMINI NAJAFABADI, M. DARABI, M.A. BARGHI, and M. RAFIEI TEHRANI, “INFLUENCE OF FORMULATION VARIABLES AND INHALATION DEVICE ON THE DEPOSITION PROFILES OF CROMOLYN SODIUM DRY POWDER AEROSOLS,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 12, no. 3, pp. 123–130, 2004, [Online]. Available: https://sid.ir/paper/275215/en

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