SOLUBILITY PREDICTION OF SULFONAMIDES AT VARIOUS TEMPERATURES USING A SINGLE DETERMINATION

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HANAEI J.; DASTMALCHI S.; ADIBKIA KH.; MIRZAZADEH AHMAD; BARZEGAR JALALI M.; JOUYBAN A.A.GH.

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Journal Paper

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Journal: DARU Journal of Pharmaceutical Sciences Year:2005 | Volume:13 | Issue:2 Page(s): 37-45

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Title

SOLUBILITY PREDICTION OF SULFONAMIDES AT VARIOUS TEMPERATURES USING A SINGLE DETERMINATION

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Keywords

SOLUBILITY; SULPHONAMIDES; MODELING; TEMPERATURE; PREDICTION

Abstract

Solubility of sulphamethoxazole, sulphisoxazole and sulphasalazine in six solvents namely water, methanol, ethanol, 1-propanol, acetone and chloroform were determined at 15, 25, 37 and 45 °C. Two models derived from the Hildebrand solubility approach are proposed for solubility prediction at different temperatures using a single determination. The experimental data of the present work as well as data gathered from the literature have been employed to investigate the accuracy and prediction capability of the proposed models. The overall percent deviations between the predicted and experimental values were 10.78 and 14.63% which were comparable to those of the classical two and three parameter models. The proposed models were much superior to the two pure predictive models i.e., the ones which do not require experimental solubility determination, as the overall percent deviations produced by the latter models were 150.09 and 161.00%.

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APA: Copy

HANAEI, J., DASTMALCHI, S., ADIBKIA, KH., MIRZAZADEH, AHMAD, BARZEGAR JALALI, M., & JOUYBAN, A.A.GH.. (2005). SOLUBILITY PREDICTION OF SULFONAMIDES AT VARIOUS TEMPERATURES USING A SINGLE DETERMINATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 13(2), 37-45. SID. https://sid.ir/paper/275242/en

Vancouver: Copy

HANAEI J., DASTMALCHI S., ADIBKIA KH., MIRZAZADEH AHMAD, BARZEGAR JALALI M., JOUYBAN A.A.GH.. SOLUBILITY PREDICTION OF SULFONAMIDES AT VARIOUS TEMPERATURES USING A SINGLE DETERMINATION. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2005;13(2):37-45. Available from: https://sid.ir/paper/275242/en

IEEE: Copy

J. HANAEI, S. DASTMALCHI, KH. ADIBKIA, AHMAD MIRZAZADEH, M. BARZEGAR JALALI, and A.A.GH. JOUYBAN, “SOLUBILITY PREDICTION OF SULFONAMIDES AT VARIOUS TEMPERATURES USING A SINGLE DETERMINATION,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 13, no. 2, pp. 37–45, 2005, [Online]. Available: https://sid.ir/paper/275242/en

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