EVALUATION EFFECT OF SILYBUM MARIANUM, CYNARA SCOLYMUS L. AND ZIZIPHUS JUJUBE MILL. COMBINATION EXTRACT ON NONALCOHOLIC FATTY LIVER IN RATS

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MOHAMMADIFAR M.; BEHNAM M.; TALAEI S.A.; KHAMECHIAN T.; MEHRAN M.; TAGHIZADEH M.

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Journal: Iranian Journal of Endocrinology & Metabolism Year:2018 | Volume:19 | Issue:6 Page(s): 410-418

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Title

EVALUATION EFFECT OF SILYBUM MARIANUM, CYNARA SCOLYMUS L. AND ZIZIPHUS JUJUBE MILL. COMBINATION EXTRACT ON NONALCOHOLIC FATTY LIVER IN RATS

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Keywords

SILYBUM MARIANUMQ1

CYNARA SCOLYMUSQ1

ZIZIPHUS JUJUBEQ1

NON-ALCOHOLIC FATTY LIVERQ1

HIGH-FAT DIETQ1

Abstract

Introduction: NON-ALCOHOLIC FATTY LIVER disease includes a spectrum of clinical syndromes from early steatosis to liver cirrhosis. The aim of this study was to evaluate the effect of combined extract of silymarin, artichoke and jujube on NON-ALCOHOLIC FATTY LIVER, induced by HIGH-FAT DIET in rats.Materials and Methods: In this experimental study, 40 male rats were divided randomly into two groups, a sham group (n=8) and a HIGH-FAT DIET group (n=32). After 4 months of being fed the HIGH-FAT DIET, rats suffering from fatty liver were divided into 4 groups (n=8 each) including a highfat diet group and the three groups receiving a dose of the combined extract 100, 200 and 400 mg/kg for 2 months. Finally, lipid profiles, activity of serum liver enzymes and liver histology were investigated.Results: The HIGH-FAT DIET increased Chol, TG and LDL and decreased HDL levels (P<0.001). This diet also increased serum activity of ALT, AST and ALP to 84, 113 and 228 %, respectively. Receiving extract at doses of 200 and 400 mg/kg improved lipid profiles and hepatic enzyme activity (P<0.05). Histopathology confirmed changes in liver induced by the high fat diet and the protective effect of the extract.Conclusion: HIGH-FAT DIET induced nonalcoholic fatty liver in rats and treatment with combined extracts of silymarin, artichoke and jujube improved the complications of the disease.

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APA: Copy

MOHAMMADIFAR, M., BEHNAM, M., TALAEI, S.A., KHAMECHIAN, T., MEHRAN, M., & TAGHIZADEH, M.. (2018). EVALUATION EFFECT OF SILYBUM MARIANUM, CYNARA SCOLYMUS L. AND ZIZIPHUS JUJUBE MILL. COMBINATION EXTRACT ON NONALCOHOLIC FATTY LIVER IN RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), 19(6 ), 410-418. SID. https://sid.ir/paper/27526/en

Vancouver: Copy

MOHAMMADIFAR M., BEHNAM M., TALAEI S.A., KHAMECHIAN T., MEHRAN M., TAGHIZADEH M.. EVALUATION EFFECT OF SILYBUM MARIANUM, CYNARA SCOLYMUS L. AND ZIZIPHUS JUJUBE MILL. COMBINATION EXTRACT ON NONALCOHOLIC FATTY LIVER IN RATS. IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM)[Internet]. 2018;19(6 ):410-418. Available from: https://sid.ir/paper/27526/en

IEEE: Copy

M. MOHAMMADIFAR, M. BEHNAM, S.A. TALAEI, T. KHAMECHIAN, M. MEHRAN, and M. TAGHIZADEH, “EVALUATION EFFECT OF SILYBUM MARIANUM, CYNARA SCOLYMUS L. AND ZIZIPHUS JUJUBE MILL. COMBINATION EXTRACT ON NONALCOHOLIC FATTY LIVER IN RATS,” IRANIAN JOURNAL OF ENDOCRINOLOGY AND METABOLISM (IJEM), vol. 19, no. 6 , pp. 410–418, 2018, [Online]. Available: https://sid.ir/paper/27526/en

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