DESIGN AND EVALUATION OF A NEW DRY POWDER INHALER

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ROUH ALAMINI NAJAFABADI A.A.H.; GILANI K.; HOZAN A.A.

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Journal Paper

Paper Information

Journal: DARU Journal of Pharmaceutical Sciences Year:2001 | Volume:9 | Issue:3-4 Page(s): 46-49

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Information Journal Paper

Title

DESIGN AND EVALUATION OF A NEW DRY POWDER INHALER

Author(s)

ROUH ALAMINI NAJAFABADI A.A.H. | GILANI K. | HOZAN A.A. | Issue Writer Certificate

Keywords

DRY POWDER INHALER

SALBUTAMOL SULFATE

TWIN IMPINGER

RESPIRABLE FRACTION

Abstract

Three versions of a new DRY POWDER INHALER (DPI), RG-haler, were designed using two kinds of grid inserts. SALBUTAMOL SULFATE/lactose blend (Ventolin Rotacaps®) was selected as a model formulation to analyze the performance of all inhalers and compare their efficiency with three marketed devices (Rotahaler®, Spinhaler® and ISF inhalator®) using the TWIN IMPINGER (TI). Deposition of the drug in device was significantly (P<0.05) lower for ISF inhalator® and all kinds of RG-halers in comparison with those of Rotahaler® and Spinhaler®. The amount of drug deposited in the stage 2 and the respirable dose for RG-halers were similar to those of ISF inhalator® and significantly (P<0.05) higher than those of Rotahaler® and Spinhaler®. The results suggest efficient aerosol generating capability of the RG-haler.

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APA: Copy

ROUH ALAMINI NAJAFABADI, A.A.H., GILANI, K., & HOZAN, A.A.. (2001). DESIGN AND EVALUATION OF A NEW DRY POWDER INHALER. DARU JOURNAL OF PHARMACEUTICAL SCIENCE, 9(3-4), 46-49. SID. https://sid.ir/paper/275293/en

Vancouver: Copy

ROUH ALAMINI NAJAFABADI A.A.H., GILANI K., HOZAN A.A.. DESIGN AND EVALUATION OF A NEW DRY POWDER INHALER. DARU JOURNAL OF PHARMACEUTICAL SCIENCE[Internet]. 2001;9(3-4):46-49. Available from: https://sid.ir/paper/275293/en

IEEE: Copy

A.A.H. ROUH ALAMINI NAJAFABADI, K. GILANI, and A.A. HOZAN, “DESIGN AND EVALUATION OF A NEW DRY POWDER INHALER,” DARU JOURNAL OF PHARMACEUTICAL SCIENCE, vol. 9, no. 3-4, pp. 46–49, 2001, [Online]. Available: https://sid.ir/paper/275293/en

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